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Boron Neutron Capture Therapy: A Renaissance

Submission deadline: 31 December 2024
Special Issue Editors
Richard A. Amos
Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom
Interests: Proton therapy; Ion beam therapy; FLASH radiotherapy; Radiotherapy physics; BNCT
Reinhard Schulte
School of Medicine, Loma Linda University , Loma Linda, United States
Interests: Hadrontherapy; Particle therapy; Particle imaging
Special Issue Information

Dear Colleagues,

Boron Neutron Capture Therapy (BNCT) is based on the preferential uptake of 10B-loaded targeting drugs by cancer cells and the high thermal neutron capture cross-section of 10B. The capture of thermal neutrons by 10B produces 4He and 7Li ions; two high-LET particles with ranges within the diameter of a single cell. This allows for the potential to target single tumor cells with precision.

BNCT is not a new idea with its conception dating back to the 1930s. However, whilst pre-clinical and clinical studies have continued, adoption of BNCT for routine clinical practice has been slow. This is primarily due to the use of reactors as a source of thermal neutrons, significantly reducing access for patients and limiting the ability to perform the necessary clinical trials. However, the development of accelerator-based BNCT systems in recent years has opened up the possibility for hospital-based installations. This is a potential game changer for the proliferation of BNCT, opening up opportunities to perform meaningful clinical trials. This advancement is causing a renaissance in the BNCT field.

Accelerator-based BNCT systems are being installed in hospitals around the world and collaborative clinical trials are planned. Work to optimize targeted drugs for improved 10B delivery is increasing and techniques for treatment planning and dose verification are being developed. This special issue will highlight cutting edge research in all these areas of BNCT development.

Keywords
Boron neutron capture therapy
BNCT
Targeted radiotherapy
High-LET
Particle therapy
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Advances in Radiotherapy & Nuclear Medicine, Electronic ISSN: 2972-4392 Published by AccScience Publishing