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Performance of neutron beam system for accelerator-based boron neutron capture therapy
Vladislav Veksleman1* ,
Mark Harrison1 ,
Kirill Martianov2 ,
Anatoly B. Muchnikov1 ,
Aleksandr Makarov2 ,
Yong Jiang3 ,
Ken Franzen1 ,
Alexander Ivanov1 ,
Michael Meekins1 ,
Chad Lee2 ,
Alexander Dunaevsky1
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1 TAE Technologies Inc., Foothill Ranch, California,
United States of America
2 TAE Life Sciences, Irvine, California,
United States of America
3 TAE TLS China, Xiamen, Fujian,
China
ARNM, 025190022 https://doi.org/10.36922/ARNM025190022
Received: 6 May 2025 | Revised: 30 July 2025 | Accepted: 4 August 2025 | Published online: 18 August 2025
(This article belongs to the Special Issue Boron Neutron Capture Therapy: A Renaissance)
© 2025 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
Abstract
A neutron beam system (NBS) based on an electrostatic proton accelerator designed for accelerator-based boron neutron capture therapy has been installed in Xiamen Humanity Hospital in China. The NBS has been used for patient treatments since October 2023, after more than a year of preliminary studies. By the end of 2024, more than 50 treatments had been executed. NBS uptime during 2024 was above 96%. Repeatability of the beam parameters was well within 2%. At present, configuration with only one treatment room operational, the overall machine usage, including clinical use, physics and dosimetry measurements, and biological experiments, has reached 27% of its capacity.
Keywords
Boron neutron capture therapy
Accelerator-based boron neutron capture therapy
Neutron beam system
Tandem accelerator
Proton beam
Lithium target
Funding
This work was fully funded by TAE Life Sciences.
Conflict of interest
Kirill Martianov, and Aleksandr Makarovand Chad Lee work for TAE Life Sciences in United States of America. This has not influenced the content of the manuscript. No reference to the author’s company is made, but it is declared for full transparency. Other authors declare no conflict of interest.
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