AccScience Publishing / AN / Online First / DOI: 10.36922/an.4771
Submit to AN
Cite this article
12
Download
155
Views
Journal Browser
Volume | Year
Issue
Search
Forthcoming Issue
Current Issue
View All
News and Announcements
View All
PERSPECTIVE ARTICLE

Thirty years of the South London Stroke Register

Eva S. Emmett1,2* ,  Fara Hamidi1,2 ,  Hatem A. Wafa1 ,  Jack Coumbe1 ,  Abdel Douiri1,2 ,  Matthew D. L. O’Connell1 ,  Ajay Bhalla1,3 ,  Iain J. Marshall1,2 ,  Charles D. A. Wolfe1,2
Show Less
1 Department of Population Health Sciences, School of Life Course and Population Sciences, King’s College London, London, United Kingdom
2 NIHR Applied Research Collaborative South London, Guy’s and St Thomas’ NHS Foundation Trust, London, United Kingdom
3 Guy’s and St Thomas’ NHS Foundation Trust, London, United Kingdom
Advanced Neurology, 4771 https://doi.org/10.36922/an.4771
Submitted: 5 September 2024 | Accepted: 25 November 2024 | Published: 12 December 2024
(This article belongs to the Special Issue Advances in stroke research and therapy)
© 2024 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
Download PDF
Cite
XML
Abstract

Since the beginning of the South London Stroke Register (SLSR) in 1995, stroke care has undergone major transformations and the SLSR adapted alongside. Recruitment strategies changed in line with patient pathways, and data collections were updated to reflect clinical practice and provide clinicians and policymakers with the most impactful data. Our Stroke Research Patient and Family group was pivotal to define the most relevant care and outcome measures for stroke survivors. The SLSR has published numerous studies on epidemiological trends and the implementation of care interventions. By providing real-world data, the SLSR has contributed to shaping local and national stroke policies, such as the UK’s National Audit Office reports 2005 and 2010, the reconfiguration of London’s stroke services and national stroke guidelines. Linking SLSR data with routinely collected health data might further address many unanswered questions around stroke as a long-term chronic condition in ageing populations.

Keywords
Stroke
Epidemiology
Cohort study
Population-based register
Funding
This project is funded by the UK’s National Institute for Health and Care Research (NIHR) under its Programme Grants for Applied Research (NIHR202339) and is supported by the NIHR Applied Research Collaboration (ARC) South London at King’s College Hospital NHS Foundation Trust, UK. The views expressed are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care (UK). The study has previously received funding from many sources including The Dunhill Medical Trust, the NIHR funding streams (Programme Grants for Applied Research and Research for Patient Benefit), the European Union, the Health Foundation, the Department of Health (UK), the Stanley Thomas Johnson Foundation, the Stroke Association and Guy’s and St Thomas’ Charity.
Conflict of interest
The authors declare no conflicts of interest.
References
  1. Feigin V, Hoorn SV. How to study stroke incidence. Lancet. 2004;363(9425):1920. doi: 10.1016/S0140-6736(04)16436-2

 

  1. Tilling K, Sterne JA, Wolfe CD. Estimation of the incidence of stroke using a capture-recapture model including covariates. Int J Epidemiol. 2001;30(6):1351-1359; discussion 1359-1360. doi: 10.1093/ije/30.6.1351

 

  1. Stewart JA, Dundas R, Howard RS, Rudd AG, Wolfe CD. Ethnic differences in incidence of stroke: Prospective study with stroke register. BMJ. 1999;318(7189):967-971. doi: 10.1136/bmj.318.7189.967

 

  1. Office for National Statistics. Census 2021: Population and Household Estimates for the United Kingdom. Office for National Statistics; 2021. Available from: https://www. nomisweb.co.uk/sources/census_2021 [Last accessed on 2023 Sep 15].

 

  1. Ministry of Housing CLG. English Indices of Deprivation; 2020. Available from: https://www.gov.uk english indices of deprivation-gov.uk [Last accessed on 2023 Jun 26].

 

  1. Redwood S, Gill PS. Under-representation of minority ethnic groups in research--call for action. Br J Gen Pract. 2013;63(612):342-343. doi: 10.3399/bjgp13X668456

 

  1. Feigin V, Norrving B, Sudlow CLM, Sacco RL. Updated Criteria for population-based stroke and transient Ischemic attack incidence studies for the 21st century. Stroke. 2018;49(9):2248-2255. doi: 10.1161/STROKEAHA.118.022161

 

  1. Marshall IJ, Wolfe C, Emmett E, et al. Cohort profile: The South London Stroke Register - a population-based register measuring the incidence and outcomes of stroke. J Stroke Cerebrovasc Dis. 2023;32(8):107210. doi: 10.1016/j.jstrokecerebrovasdis.2023.107210

 

  1. Heuschmann PU, Wiedmann S, Wellwood I, et al. Three-month stroke outcome: The European Registers of Stroke (EROS) investigators. Neurology. 2011;76(2):159-165. doi: 10.1212/WNL.0b013e318206ca1e

 

  1. Heuschmann PU, Grieve AP, Toschke AM, Rudd AG, Wolfe CD. Ethnic group disparities in 10-year trends in stroke incidence and vascular risk factors: The South London Stroke Register (SLSR). Stroke. 2008;39(8):2204-2210. doi: 10.1161/strokeaha.107.507285

 

  1. Wang Y, Rudd AG, Wolfe CD. Age and ethnic disparities in incidence of stroke over time: The South London Stroke Register. Stroke. 2013;44(12):3298-3304. doi: 10.1161/STROKEAHA.113.002604

 

  1. Wafa HA, Wolfe CDA, Rudd A, Wang Y. Long-term trends in incidence and risk factors for ischaemic stroke subtypes: Prospective population study of the South London Stroke Register. PLoS Med. 2018;15(10):e1002669. doi: 10.1371/journal.pmed.1002669

 

  1. Flach C, Muruet W, Wolfe CDA, Bhalla A, Douiri A. Risk and secondary prevention of stroke recurrence: A population-base cohort study. Stroke. 2020;51(8):2435-2444. doi: 10.1161/STROKEAHA.120.028992

 

  1. Marshall IJ, Wang Y, McKevitt C, Rudd AG, Wolfe CD. Trends in risk factor prevalence and management before first stroke: Data from the South London Stroke Register 1995-2011. Stroke. 2013;44(7):1809-1816. doi: 10.1161/strokeaha.111.000655

 

  1. Wafa HA, Wolfe CDA, Bhalla A, Wang Y. Long-term trends in death and dependence after ischaemic strokes: A retrospective cohort study using the South London Stroke Register (SLSR). PLoS Med. 2020;17(3):e1003048. doi: 10.1371/journal.pmed.1003048

 

  1. Wang Y, Rudd AG, Wolfe CD. Trends and survival between ethnic groups after stroke: The South London Stroke Register. Stroke. 2013;44(2):380-387. doi: 10.1161/strokeaha.112.680843

 

  1. Wolfe CD, Crichton SL, Heuschmann PU, et al. Estimates of outcomes up to ten years after stroke: Analysis from the prospective South London Stroke Register. PLoS Med. 2011;8(5):e1001033. doi: 10.1371/journal.pmed.1001033

 

  1. Ayerbe L, Ayis S, Crichton S, Wolfe CD, Rudd AG. The natural history of depression up to 15 years after stroke: The South London Stroke Register. Stroke. 2013;44(4):1105-1110. doi: 10.1161/STROKEAHA.111.679340

 

  1. Ayerbe L, Ayis S, Rudd AG, Heuschmann PU, Wolfe CD. Natural history, predictors, and associations of depression 5 years after stroke: The South London Stroke Register. Stroke. 2011;42(7):1907-1911. doi: 10.1161/STROKEAHA.110.605808

 

  1. Douiri A, Rudd AG, Wolfe CD. Prevalence of poststroke cognitive impairment: South London Stroke Register 1995- 2010. Stroke. 2013;44(1):138-145. doi: 10.1161/STROKEAHA.112.670844

 

  1. Douiri A, McKevitt C, Emmett ES, Rudd AG, Wolfe CD. Long-term effects of secondary prevention on cognitive function in stroke patients. Circulation. 2013;128(12):1341-1348. doi: 10.1161/CIRCULATIONAHA.113.002236

 

  1. Addo J, Bhalla A, Crichton S, Rudd AG, McKevitt C, Wolfe CD. Provision of acute stroke care and associated factors in a multiethnic population: Prospective study with the South London Stroke Register. BMJ. 2011;342:d744. doi: 10.1136/bmj.d744

 

  1. Muruet W, Rudd A, Wolfe CDA, Douiri A. Long-term survival after intravenous thrombolysis for Ischemic stroke: A propensity score-matched cohort with up to 10-year follow-up. Stroke. 2018;49(3):607-613. doi: 10.1161/STROKEAHA.117.019889

 

  1. Addo J, Crichton S, Bhalla A, Rudd AG, Wolfe CD, McKevitt C. Impact of implementing evidence-based acute stroke interventions on survival: The South London Stroke Register. PLoS One. 2013;8(4):e61581. doi: 10.1371/journal.pone.0061581

 

  1. Rudd AG, Wolfe CD, Tilling K, Beech R. Randomised controlled trial to evaluate early discharge scheme for patients with stroke. BMJ. 1997;315(7115):1039-1044. doi: 10.1136/bmj.315.7115.1039

 

  1. Department of Health. Reducing Brain Damage: Faster Access to Better Stroke Care. London, UK: National Audit Office; 2005. Available from: https://www.nao.org.uk/ reports/department-of-health-reducing-brain-damage-faster-access-to-better-stroke-care [Last accessed on 2023 Oct 15].

 

  1. Department of Health. National Stroke Strategy. London, UK: National Audit Office; 2007.

 

  1. Department of Health. Progress in Improving Stroke Care. London, UK: National Audit Office; 2010.

 

  1. Fulop NJ, Ramsay AIG, Hunter RM, et al. Evaluation of reconfigurations of acute stroke services in different regions of England and lessons for implementation: A mixed-methods study. Health Serv Deliv Res. 2019;7(7). doi: 10.3310/hsdr07070

 

  1. Marshall I, McKevitt C, Wang Y, et al. Stroke pathway - An evidence base for commissioning - An evidence review for NHS England and NHS Improvement. NIHR Open Res. 2022;2:43. doi: 10.3310/nihropenres.13257.1

 

  1. Intercollegiate Stroke Working Party. National Clinical Guideline for Stroke for the UK and Ireland; 2023. Available from: https://www.strokeguideline.org [Last accessed on 2023 Oct 15].
Share
Back to top
Advanced Neurology, Electronic ISSN: 2810-9619 Print ISSN: 3060-8589, Published by AccScience Publishing
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here
Accept