Modernism in architecture has witnessed the erosion of traditions, art, culture, and beliefs of Indigenous southwestern Nigerians in recent architectural developments. This phenomenon has stripped most modern buildings, especially in southwestern Nigeria, of their cultural values. This study delves into the historical context of Nigerian art and architecture, highlighting the need for a paradigm shift toward a more culturally inclusive approach. It investigates various strategies and presents examples of successful integration, including the utilization of traditional materials, incorporation of indigenous motifs, and collaboration with local artists and craftsmen. This research examines three cultural center buildings where the architects have endeavored to integrate the art and culture of the people of southwestern Nigeria into contemporary architecture. The case study method of inquiry was adopted for this research, combined with detailed observation and analysis of digital photographs of these buildings. The study highlights the relevance of art and culture in recent architectural developments in three southwestern Nigerian cities: Akure, Benin, and Ibadan. These cities were selected because of their historical backgrounds and rich cultural affiliations that reflect the art and lifestyle of their localities. The cases studied were cultural center buildings because these building types are purposely built to reflect the culture of the people. Findings from the study reveal that some modern buildings still imbibe the art and culture of the people, while others incorporate these elements in more subtle ways, such as mural paintings and relief sculptures on walls. These features connote cultural expressions and representations of Nigeria’s heritage, which should not be forgotten but preserved for future generations.