AccScience Publishing / MSAM / Volume 2 / Issue 2 / DOI: 10.36922/msam.0620
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REVIEW

Advanced approaches with combination of 2D nanomaterials and 3D printing for exquisite neural tissue engineering

Hyo Jung Jo1 Moon Sung Kang1 Hee Jeong Jang1 Iruthayapandi Selestin Raja2 Dohyung Lim3 Bongju Kim4* Dong-Wook Han1,2*
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1 Department of Cogno-Mechatronics Engineering, Pusan National University, Busan 46241, South Korea
2 BIO-IT Fusion Technology Research Institute, Pusan National University, Busan 46241, South Korea
3 Department of Mechanical Engineering, Sejong University, Seoul 05006, South Korea
4 Dental Life Science Research Institute/Innovation Research and Support Center for Dental Science, Seoul National University Dental Hospital, Seoul 03080, South Korea
Submitted: 19 April 2023 | Accepted: 23 May 2023 | Published: 7 June 2023
© 2023 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
Abstract

The regeneration of neural tissue presents significant challenges due to the complexity of the nervous system, which can be damaged by traumatic and non-traumatic injuries. Traditional approaches to repairing nerve damage, such as transplantation of auto-, allo-, or xeno-grafts, have limitations. Recently, researchers have been studying the use of two-dimensional (2D) nanomaterials as novel therapeutic approaches for treating neurological disorders. This review first presents the classification of 2D nanoparticles for neural regeneration and their biocompatibility. Thereafter, we discuss the recent approaches combining 2D nanomaterials and three-dimensional (3D) printing to produce hydrogel-based scaffolds for exquisite neural tissue engineering. Furthermore, recent highlighted studies focusing on the combination of 2D nanomaterials and 3D bioprinting for neural tissue engineering are specially introduced. Through this review, we aim to contribute to crafting a range of strategies for the biomedical applications of 3D printing with diverse nanomaterials and hope to encourage further research on understanding the mechanisms of toxicity as well as the synergistic effects of 2D nanomaterials and hydrogel scaffolds for neural tissue engineering and regeneration.

Keywords
3D Printing
2D Nanomaterials
Hydrogel
Neural tissue engineering
Biocompatibility
Funding
This research was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (No. 2021R1A2C2006013), Basic Science Research Program through the NRF funded by the Ministry of Education (No. 2022R1I1A1A01064416), the Korea Evaluation Institute of Industrial Technology (KEIT) grant funded by the Ministry of Trade, Industry, and Energy (MOTIE, Korea) (No. 20014399), and the Korea Health Technology R&D Project through Korea Health Industry Development Institute (KHIDI) funded by the Ministry of Health and Welfare (MOHW, Korea) (No. HI21C0167).
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Conflict of interest
The authors have no relevant financial or non-financial interests to disclose.
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