AccScience Publishing / JCBP / Volume 1 / Issue 2 / DOI: 10.36922/jcbp.1130
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ORIGINAL RESEARCH ARTICLE

Mutuality of thyroid hormones and psychiatric disorders

Sandra Vuk Pisk1,2* ,  Natko Gereš1,2 ,  Karla Laškarin1 ,  Katarina Matić1 ,  Nedjeljka Ruljančić1 ,  Ena Ivezić1,2 ,  Igor Filipčić1,2,3
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1 Department of Integrative Psychiatry, University Psychiatric Hospital Sveti Ivan, Zagreb, Croatia
2 Department of Psychiatry and Neurology, Faculty of Dental Medicine and Health, “Josip Juraj Strossmayer” University of Osijek, Osijek, Croatia
3 Department of Psychiatry and Neurology, School of Medicine, University of Zagreb, Zagreb, Croatia
JCBP 2023, 1(2), 1130 https://doi.org/10.36922/jcbp.1130
Submitted: 25 June 2023 | Accepted: 23 August 2023 | Published: 20 September 2023
© 2023 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
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Abstract

Abnormalities in thyroid function may induce affective, anxious, psychotic, and cognitive disorders and are a potential marker for assessing suicidal risk in patients suffering from psychiatric disorders. This retrospective, cross-sectional, electronic, and data-based study, comprising 118 adult psychiatric patients, aimed to establish differences in the concentrations of total T3, T4, and thyroid-stimulating hormone among patients diagnosed with common psychiatric disorders. The analysis encompassed the levels of these hormones in patients who had attempted suicide and those who had not. Lower values of total T3 were observed in patients with depressive disorder compared to patients with psychotic and bipolar disorder, as well as the control group. Furthermore, lower total T3 values were observed in patients who had reported a suicide attempt in their lives compared to participants who had not attempted suicide. These findings suggest a potential link between thyroid hormones and the regulation of central serotonin activity. The study underscores the importance of routinely assessing thyroid function in clinical practice to facilitate early detection of suicidality and the prevention of suicide.

Keywords
Thyroid hormones
Hypothalamic-pituitary-adrenal axis
Suicide prevention
Psychiatric disorders
Suicidality
Funding
None.
Conflict of interest
The authors declare that they have no competing interests.
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