This Special Issue centers on the role of 3D bioprinting in advancing pancreatic cancer research through precise tumor models. Pancreatic cancer poses significant challenges due to its complex biology and treatment resistance. By leveraging 3D bioprinting, researchers can replicate the architecture and microenvironment of pancreatic tumors, leading to more effective in vitro models. We invite submissions focused exclusively on innovative bioprinting applications for pancreatic cancer, including scaffold fabrication, biomaterial optimization, and engineered cell constructs. Emphasis should be on how bioprinting enhances understanding of tumor biology, drug resistance, and tumor-stroma interactions. This Special Issue consolidates cutting-edge research on bioprinting as a crucial tool in pancreatic cancer studies, addressing the unique challenges of this disease. Papers with no bioprinting will be rejected.