This Special Issue aims to highlight cutting-edge advancements in bioprinting technologies and their application to both foundational and clinical aspects of oncology, including tumor modeling, diagnostics, drug screening, and therapeutic development.

Bioprinting has emerged as a transformative tool for creating biomimetic tumor models that closely replicate the complexity of the tumor microenvironment. These models enable detailed investigation into tumor biology, metastasis, and drug resistance, while also paving the way for personalized medicine approaches. Furthermore, bioprinting holds immense potential for developing diagnostic platforms, drug delivery systems, and regenerative strategies for cancer treatment.

Scope and Topics

This Special Issue seeks to showcase original research articles, reviews, and perspectives that explore the intersection of bioprinting and oncology. Topics of interest include, but are not limited to:

Bioprinted Tumor Models: 3D in vitro models of solid tumors, tumor Organoids, tumor-stroma interactions, vascularized tumor constructs, and metastatic niche models.

Bioprinting for Tumor Microenvironment Engineering: Spatially controlled, multi-material bioprinting strategies to fabricate biomimetic 3D tumor models that precisely integrate immune cells, fibroblasts, vasculature, and extracellular matrix components with structural and biological fidelity.

Bioprinting for Diagnostic Applications: Bioprinted platforms for cancer detection, biomarker analysis, and patient-specific diagnostic tools.

Bioprinting for Drug Screening and Development：Leveraging high-throughput bioprinting and automated biofabrication platforms to generate reproducible, patient-specific 3D tumor models or multicellular tumor organoid or patient-derived tumor organoids for the systematic evaluation of anticancer drug efficacy, toxicity, and resistance mechanisms.

Bioprinting for Cancer Therapy: Biofabrication of drug delivery systems, immunotherapeutic scaffolds, and post-resection tissue reconstruction.

Bioprinting for Clinical Translation: Challenges and opportunities in applying bioprinting technologies to clinical oncology, including regulatory and ethical considerations.

By bringing together innovative studies and critical reviews, this Special Issue aims to foster collaboration and accelerate progress in bioprinting for cancer research and treatment.