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Potential of bioprinted intestine-on-chip models in advancing understanding of human coronavirus infections and drug screening

Min-Hyeok Kim1 ,  Jeeyeon Lee2 ,  Chwee Teck Lim2,3,4 ,  Sungsu Park1,5*
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1 School of Mechanical Engineering, Sungkyunkwan University (SKKU), Suwon, Republic of Korea
2 Institute for Health Innovation and Technology (iHealthtech), National University of Singapore, Singapore
3 Department of Biomedical Engineering, National University of Singapore, Singapore
4 Mechanobiology Institute, National University of Singapore, Singapore
5 Department of Biophysics, Institute of Quantum Biophysics (IQB), Sungkyunkwan University (SKKU), Suwon, Republic of Korea
IJB 2024, 10(2), 1704 https://doi.org/10.36922/ijb.1704
Submitted: 29 August 2023 | Accepted: 9 November 2023 | Published: 23 January 2024
(This article belongs to the Special Issue Role of 3D Printing Processes in Medicine)
© 2024 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
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Abstract

Human coronaviruses, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), contribute to both respiratory and gastrointestinal symptoms, necessitating a comprehensive approach to studying viral pathogenesis. In this context, bioprinted intestine-on-chip models offer a cutting-edge technology for closely replicating the tissue architecture and microenvironment of the human intestine, providing valuable insights into viral dynamics and host responses. Integration of intestinal organoids with organoid-on-chip technology enhances the accuracy of modeling SARS-CoV-2 infection by means of improving cellular differentiation and virus-binding receptor expression. Furthermore, bioprinting technology allows for automated fabrication, enabling high-throughput drug screening on the intestine-on-chip platform. These advancements in bioprinted intestine-on-chip models hold immense promise for advancing our understanding of coronavirus infection in the gut and accelerating drug development, ultimately contributing to improved patient outcomes and public health measures.

Keywords
Intestine
Bioprinting
Organ-on-chip
Coronavirus
Drug screening
Funding
This work was supported by both the SKKU Global Research Platform Research Fund (Sungkyunkwan University, 2022; No. RS-2023-00218543) and the National Research Foundation of Korea (NRF) grants funded by the Korea government (MSIT; No. RS-2023-00242443).
Conflict of interest
The authors declare no conflicts of interest.
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International Journal of Bioprinting, Electronic ISSN: 2424-8002 Print ISSN: 2424-7723, Published by AccScience Publishing
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