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REVIEW

Research progress of 3D-bioprinted functional pancreas and in vitro tumor models

Liusheng Wu1,2† ,  Huansong Li3† ,  Yangsui Liu3† ,  Zhengyang Fan4† ,  Jingyi Xu1† ,  Ning Li5† ,  Xinye Qian1 ,  Zewei Lin6* ,  Xiaoqiang Li2* ,  Jun Yan1*
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1 Beijing Tsinghua Chang Gung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China
2 Department of Thoracic Surgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China
3 Hepatobiliary Pancreatic Center, Xuzhou Central Hospital, Xuzhou, Jiangsu, China
4 Department of Graduate School, Xinjiang Medical University, Urumqi, Xinjiang, China
5 Graduate School of Qinghai University, Xining, Qinghai, China
6 Department of Hepatological Surgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China
IJB 2024, 10(1), 1256 https://doi.org/10.36922/ijb.1256
Submitted: 5 September 2023 | Accepted: 27 September 2023 | Published: 3 January 2024
(This article belongs to the Special Issue Advances in Bioprinting for Medical Applications)
© 2024 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
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Abstract

With the rapid development of three-dimensional (3D) bioprinting technology, the research revolving around in vitro functional pancreas and tumor models has become the focus of attention in the field of life sciences. This review aims to summarize and deeply discuss the research progress and prospects of 3D-bioprinted functional pancreas and in vitro tumor models. The efforts in improving 3D printing technology to increase its accuracy and reliability in the biomedical applications have been ramped up over the past few years. Researchers are now able to create highly complex 3D structures through precise layering of biological materials at the micron scale. For instance, a functional pancreas can be printed in vitro by combining cells, biomaterials, and growth factors. The introduction of new technologies allows researchers to more accurately simulate the growth and spread of tumors, providing a more realistic platform for cancer treatment research. This not only helps accelerate the process of drug screening, but also lays the foundation for personalized medicine. As multiple disciplines, such as materials science, cell biology, and engineering, continue to converge with 3D bioprinting, emergence of more innovative applications is anticipated. However, despite significant progress, many technical and ethical challenges still need to be overcome before practical clinical applications can be implemented. In summary, the application of bioprinting technology is of great significance to the study of functional pancreas and in vitro tumor models, which could lead to new breakthroughs in the development of clinical treatment and personalized medicine.

Keywords
3D bioprinting technology
In vitro functional pancreatic model
In vitro pancreatic cancer model
Artificial intelligence programming technology
Funding
This work was supported by Scientific Research Project of Education Department of Anhui Province (YJS20210324), the National Natural Science Foundation of China (81972829), the Scientific Research Foundation of Peking University Shenzhen Hospital (KYQD202100X), Research and Development of Intelligent Surgical Navigation and Operating System for Precise Liver Resection (2022ZLA006), Start-up Fund for Talent Researchers of Tsinghua University (10001020507), and National Science and Technology Major Project of China (2017ZX100203205).
Conflict of interest
The authors declare no competing conflicts of interest.
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International Journal of Bioprinting, Electronic ISSN: 2424-8002 Print ISSN: 2424-7723, Published by AccScience Publishing
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