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REVIEW

Three-dimensional bioprinting for musculoskeletal regeneration and disease modeling

Qiang Wei1† ,  Yuhao Peng1† ,  Weicheng Chen1 ,  Yudong Duan1 ,  Genglei Chua1 ,  Jie Hu1 ,  Shujun Lyu2 ,  Zhigang Chen2* ,  Fengxuan Han1* ,  Bin Li1*
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1 Medical 3D Printing Center, Orthopaedic Institute, Department of Orthopaedic Surgery, The First Affiliated Hospital, School of Biology and Basic Medical Sciences, Suzhou Medical College, Soochow University, Suzhou 215006, China
2 Department of Orthopaedic Surgery, The Affiliated Hai’an Hospital of Nantong University, Hai’an, Nantong 226600, China
IJB 2024, 10(1), 1037 https://doi.org/10.36922/ijb.1037
Submitted: 3 June 2023 | Accepted: 31 July 2023 | Published: 2 January 2024
(This article belongs to the Special Issue The Latest Advances of Bioinks for 3D Bioprinting)
© 2024 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
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Abstract

Musculoskeletal disease and injury are highly prevalent disorders that impose tremendous medical and socioeconomic burdens. Tissue engineering has attracted increasing attention as a promising technique of regenerative medicine to restore degenerative or damaged tissues and is used to produce functional disease models. As a revolutionary technology, three-dimensional (3D) bioprinting has demonstrated a considerable potential in enhancing the versatility of tissue engineering. 3D bioprinting allows for the rapid and accurate spatial patterning of cells, growth factors, and biomaterials to generate biomimetic tissue constructs. Meanwhile, 3D-bioprinted in vitro models also offer a viable option to enable precise pharmacological interventions in various diseases. This review provides an overview of 3D bioprinting methods and bioinks for therapeutic applications and describes their potential for musculoskeletal tissue regeneration. We also highlight the fabrication of 3D-bioprinted models for drug development targeting musculoskeletal disease. Finally, the existing challenges and future perspectives of 3D bioprinting for musculoskeletal regeneration and disease modeling are discussed.

Keywords
3D bioprinting; Bioink; Musculoskeletal tissue; Regeneration; Disease modeling
Funding
This work was funded by the National Natural Science Foundation of China (81925027, 32130059, 32171350), the Medical and Health Science and Technology Innovation Project of Suzhou (SKY2022105), and the Priority Academic Program Development of Jiangsu Higher Education Institutions.
Conflict of interest
The authors declare no conflict of interests.
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International Journal of Bioprinting, Electronic ISSN: 2424-8002 Print ISSN: 2424-7723, Published by AccScience Publishing
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