AccScience Publishing / IJB / Volume 9 / Issue 1 / DOI: 10.18063/ijb.v9i1.648
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RESEARCH ARTICLE

Multifunctional 3D platforms for rapid hemostasis and wound healing: Structural and functional prospects at biointerfaces

Keya Ganguly1† Maria Mercedes Espinal1† Sayan Deb Dutta1 Dinesh K. Patel3 Tejal V. Patil1,2 Rachmi Luthfikasari1 Ki-Taek Lim1,2,3*
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1 Department of Biosystems Engineering, Kangwon National University, Chuncheon 24341, Republic of Korea
2 Interdisciplinary Program in Smart Agriculture, Kangwon National University, Chuncheon 24341, Republic of Korea
3 Institute of Forest Science, Kangwon National University, Chuncheon 24341, Republic of Korea
Submitted: 14 June 2022 | Accepted: 29 August 2022 | Published: 29 November 2022
© 2022 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
Abstract

Fabrication of multifunctional hemostats is indispensable against chronic blood loss and accelerated wound healing. Various hemostatic materials that aid wound repair or rapid tissue regeneration has been developed in the last 5 years. This review provides an overview of the three-dimensional (3D) hemostatic platforms designed through the latest technologies like electrospinning, 3D printing, and lithography, solely or in combination, for application in rapid wound healing. We critically discuss the pivotal role of micro/nano-3D topography and biomaterial properties in mediating rapid blood clots and healing at the hemostat-biointerface. We also highlight the advantages and limitations of the designed 3D hemostats. We anticipate that this review will guide the fabrication of smart hemostats of the future for tissue engineering applications.

Keywords
Multifunctional hemostats
Wound healing
Micro/nano-3D topography
Hemostat-biointerface
Tissue engineering
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International Journal of Bioprinting, Electronic ISSN: 2424-8002 Print ISSN: 2424-7723, Published by AccScience Publishing