AccScience Publishing / IJB / Volume 10 / Issue 3 / DOI: 10.36922/ijb.1829
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RESEARCH ARTICLE

Polydopamine chelating strontium on graphene oxide enhances the mechanical and osteogenic induction properties of PLLA/PGA bone scaffold 

Feng Yang1† ,  Yun Lin1† ,  Saipu Shen1 ,  Yulong Gu1 ,  Cijun Shuai1,2,3* ,  Pei Feng1*
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1 State Key Laboratory of Precision Manufacturing for Extreme Service Performance, College of Mechanical and Electrical Engineering, Central South University, Changsha, Hunan, China
2 Institute of Additive Manufacturing, Jiangxi University of Science and Technology, Nanchang, Jiangxi, China
3 College of Mechanical Engineering, Xinjiang University, Urumqi, Xinjiang, China
IJB 2024, 10(3), 1829 https://doi.org/10.36922/ijb.1829
Submitted: 13 September 2023 | Accepted: 17 November 2023 | Published: 12 January 2024
© 2024 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
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Abstract

Poly (lactic acid)/poly (glycolic acid) (LG) bone scaffold exhibits good biocompatibility for bone defect regeneration but lacks satisfactory mechanical and osteogenic induction properties. Here, graphene oxide (GO) was encapsulated by polydopamine (PDA) via self-polymerization of dopamine, and strontium (Sr) was loaded onto GO by the chelation of PDA. The modified GO was added to the LG scaffold prepared via selective laser sintering as a reinforcing phase to improve the mechanical properties and osteogenic induction properties. The results indicated that the tensile and compressive strengths of the scaffold with 1.5 wt% modified GO were 9.49 MPa and 19.22 MPa, respectively, representing 67.08% and 95.33% improvement compared to the LG scaffold. The enhancement mechanisms of the modified GO in the scaffold included crack branching, crack deflection, crack pinning, crack bridging, and pulling out. More importantly, the scaffold with modified GO exhibited superior bioactivity and osteogenic induction properties compared to the LG scaffold, because PDA could chelate calcium ions derived from the surrounding physiological environment, and the calcium ions attracted phosphate ions through electrostatic interactions to promote the apatite layer deposition. Additionally, the presence of Sr in the scaffold promoted the proliferation and differentiation of osteoblasts, thereby improving osteogenic induction properties.

Keywords
Graphene oxide
Polydopamine
Strontium
Mechanical properties
Osteogenic induction properties
Funding
This work was supported by the following funds: (1) The Natural Science Foundation of China (52275393, 51935014, 82072084); (2) Hunan Provincial Natural Science Foundation of China (2021JJ20061, 2020JJ3047, 2019JJ50588); (3) Jiangxi Provincial Natural Science Foundation of China (20224ACB204013); (4) The Project of State Key Laboratory of Precision Manufacturing for Extreme Service Performance; (5) Technology Innovation Platform Project of Shenzhen Institute of Information Technology 2020 (PT2020E002); (6) Guangdong Province Precision Manufacturing and Intelligent production education Integration Innovation Platform (2022CJPT019).
Conflict of interest
The authors declare no conflicts of interest.
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International Journal of Bioprinting, Electronic ISSN: 2424-8002 Print ISSN: 2424-7723, Published by AccScience Publishing
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