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Inhibiting oxidative stress and inflammation in acute lung injury using hydrogen: A preclinical systematic review and meta-analysis

Guoshen Zhong1† ,  Yanhua Shi1 ,  Lingyu Kong2† ,  Kaixuan Lv3 ,  Lichun Zhang1 ,  Mei Yang1 ,  Na Tian4* ,  Nana Yang1*
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1 School of Life Science and Technology, Weifang Medical University, Weifang, 261053, China
2 Physical Education and Sports School, Soochow University, Suzhou, 215021, China
3 State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, 650032, China
4 School of Public Health, Weifang Medical University, Weifang, 261053, China
Global Translational Medicine 2023, 2(3), 0379 https://doi.org/10.36922/gtm.0379
Submitted: 30 March 2023 | Accepted: 12 July 2023 | Published: 11 August 2023
© 2023 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
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Abstract

Acute lung injury (ALI) results from excessive inflammation and disruption of the alveolar-capillary barrier, leading to acute respiratory distress syndrome. Hydrogen, known as a reducing substance, has been commonly used in preclinical trials of ALI. The present paper aims to summarize the effects of hydrogen on animal models of ALI and the possible antioxidant and anti-inflammation mechanisms of hydrogen. We conducted a thorough search of the relevant literature on PubMed, EMBASE, Web of Science, and CNKI. Data retrieved from 20 studies were analyzed to assess the beneficial effects of hydrogen therapy on ALI animal models. To evaluate the effects of hydrogen, commonly assessed outcome indicators include wet-to-dry ratio (W/D), arterial oxygen partial pressure (PaO2), malondialdehyde (MDA), superoxide dismutase (SOD), and tumor necrosis factor-alpha (TNF-α). The results demonstrate that hydrogen reduces pulmonary edema (W/D: 95% CI = −0.98 – −0.85, P < 0.001), mitigates hypoxia (PaO2: 95% CI = 6.08 – 22.30, P < 0.001), represses lipid peroxidation (MDA: 95% CI = −2.12 – −1.06, P < 0.001), scavenges free radicals (SOD: 95% CI = 10.12 – 30.07, P < 0.001), and inhibits inflammatory response (TNF-α: 95% CI = −5.52 – −1.72, P < 0.001). The subgroup analysis showed significant differences between interventions (MDA: P < 0.05; TNF-α: P < 0.05; SOD: P < 0.001). The meta-regression suggests that species may cause heterogeneity (P < 0.05). These results suggest the potential of using hydrogen in clinical trials. Different interventions with hydrogen can affect metabolic transport and distribution in vivo. Further studies should be conducted to validate and confirm these findings.

Keywords
Pharmacology
Inflammation
Acute lung injury
Preclinical study
Meta-analysis
Funding
National Natural Science Foundation of China
Province Natural Science Foundation of Shandong
Province Science and Technology Development Foundation of Shandong
Introduction Plan of Young Creative Talents in Colleges and Universities of Shandong Province
Shandong Province Technology Contract
Conflict of interest
The authors declare that there is no conflict of interest regarding the publication of this article.
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