News and Announcements
BRIEF REPORT
Non-surgical treatment of periodontal intrabony defects using rhPDGF-BB-saturated collagen sponges
Show Less
1
Department of Periodontics, School of Dentistry, University of Loma Linda, Loma Linda, California,
United States of America
2
Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, Michigan,
United States of America
3
Department of Periodontics and Oral Medicine, School of Dentistry, Nova Southeastern University, Fort Lauderdale,
United States of America
4
Department of General Dentistry, School of Dentistry, University of Southern California, Los Angeles, California,
United States of America
Global Translational Medicine, 3313 https://doi.org/10.36922/gtm.3313
Submitted: 29 March 2024 | Accepted: 28 May 2024 | Published: 4 September 2024
© 2024 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
Abstract
This study evaluated the use of a collagen sponge soaked with recombinant human platelet-derived growth factor-BB for non-surgical treatment of intrabony defects in the esthetic zone. After 6 months of follow-up, this technique demonstrated positive outcomes, including reduced probing depth and improved attachment levels, indicative of periodontal regeneration. The notable improvement in clinical parameters indicates that this approach could be a viable non-surgical alternative with clinical outcomes comparable to current surgical procedures.
Keywords
Periodontal regeneration
Esthetic
Recombinant human platelet-derived growth factor-BB
Funding
None.
Conflict of interest
The authors declare no conflict of interest.
References
- Anoixiadou S, Parashis A, Vouros I. Minimally invasive non-surgical technique in the treatment of intrabony defects-a narrative review. Dent J (Basel). 2023;11(1):25. doi: 10.3390/dj11010025
- Nibali L, Koidou V, Salomone S, et al. Minimally invasive non-surgical vs. Surgical approach for periodontal intrabony defects: A randomised controlled trial. Trials. 2019;20(1):461. doi: 10.1186/s13063-019-3544-8
- Sarment DP, Cooke JW, Miller SE, et al. Effect of rhPDGF-BB on bone turnover during periodontal repair. J Clin Periodontol. 2006;33(2):135-140. doi: 10.1111/j.1600-051X.2005.00870.x
- Urban I, Caplanis N, Lozada JL. Simultaneous vertical guided bone regeneration and guided tissue regeneration in the posterior maxilla using recombinant human platelet-derived growth factor: A case report. J Oral Implantol. 2009;35(5):251-256. doi: 10.1563/AAID-JOI-D-09-00004.1
- Kao RT, Nares S, Reynolds MA. Periodontal regeneration-intrabony defects: A systematic review from the AAP Regeneration Workshop. J Periodontol. 2015;86(2 Suppl):S77-S104. doi: 10.1902/jop.2015.130685
- Tavelli L, Ravidà A, Barootchi S, Chambrone L, Giannobile WV. Recombinant human platelet-derived growth factor: A systematic review of clinical findings in oral regenerative procedures. JDR Clin Trans Res. 2021;6(2):161-173. doi: 10.1177/2380084420921353
- Cosola S, Oldoini G, Giammarinaro E, Covani U, Genovesi A, Marconcini S. The effectiveness of the information-motivation model and domestic brushing with a hypochlorite-based formula on peri-implant mucositis: A randomized clinical study. Clin Exp Dent Res. 2022;8(1):350-358. doi: 10.1002/cre2.487
- Aiuto R, Torchia V, De Giorgio S, Paglia L. Survey on women’s awareness of the importance of oral hygiene during pregnancy for the health of the mother and her unborn child: Observational aepidemiological study. Eur J Paediatr Dent. 2020;21:55-60. doi: 10.23804/ejpd.2020.21.01.11
- Wu YC, Lin LK, Song CJ, Su YX, Tu YK. Comparisons of periodontal regenerative therapies: A meta-analysis on the long-term efficacy. J Clin Periodontol. 2017;44(5):511-519. doi: 10.1111/jcpe.12715
- Nocini PF, Menchini Fabris GB, Gelpi F, et al. Treatment of skin defects with growth factors and biodegradable collagen carrier: Histological evaluation in animal model. J Biol Regul Homeost Agents. 2017;31(2 Suppl 2):1-13.