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REVIEW

Effects of flavonoids on vascular activity

Sadettin Demirel1* ,  Dursun Alper Yilmaz2
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1 Department of Physiology, Faculty of Medicine, Bursa Uludag University, Bursa, Bursa Province, Türkiye
2 Department of Nursing, Faculty of Health Sciences, Agri Ibrahim Cecen University, Agri, Agri Province, Türkiye
Global Translational Medicine 2024, 3(2), 2458 https://doi.org/10.36922/gtm.2458
Submitted: 17 December 2023 | Accepted: 25 March 2024 | Published: 19 June 2024
© 2024 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
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Abstract

Flavonoids, encompassing various polyphenolic compounds found in plants, exert significant effects on vascular function. Particularly notable is their role in inducing vasodilation, a process crucial for regulating blood pressure (BP) and enhancing cardiovascular health. Through their vasodilatory properties, flavonoids contribute to improved blood flow and endothelial function. In addition, flavonoids demonstrate antiplatelet effects, which play a vital role in preventing abnormal blood clot formation and reducing the risk of thrombotic events. By inhibiting platelet aggregation, flavonoids help maintain vascular integrity and mitigate the likelihood of cardiovascular complications. In addition to vasodilation and antiplatelet effects, flavonoids exhibit potential benefits in managing hypertension. Studies suggest that flavonoids can help regulate BP by promoting vasorelaxation and modulating endothelial function. These mechanisms contribute to the overall maintenance of cardiovascular homeostasis and may offer therapeutic avenues for hypertension management. This review aims to comprehensively explore the multifaceted effects of flavonoids on vascular function, with an emphasis on their vasodilatory properties, antiplatelet effects, and potential implications for hypertension management within the existing literature.

Keywords
Atherosclerosis
Flavonoid
Hypertension
Vascular functions
Funding
None.
Conflict of interest
The authors declare no conflicts of interest.
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