AccScience Publishing / GTM / Online First / DOI: 10.36922/gtm.2669
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ORIGINAL RESEARCH ARTICLE

Evaluating machine learning models for prediction of coronary artery disease

Rejath Jose1 ,  Anvin Thomas1 ,  Jennifer Guo1 ,  Robert Steinberg1 ,  Milan Toma1*
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1 Department of Osteopathic Manipulative Medicine, College of Osteopathic Medicine, New York Institute of Technology, Old Westbury, New York, United States of America
Global Translational Medicine 2024, 3(1), 2669 https://doi.org/10.36922/gtm.2669
Submitted: 8 January 2024 | Accepted: 12 March 2024 | Published: 22 March 2024
© 2024 by the Author (s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
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Abstract

Coronary artery disease (CAD) is a prevailing global health issue and a leading cause of death worldwide. Its accurate and timely diagnosis is crucial for effectively managing the disease and improving patient outcomes. In this study, we conducted a comparative analysis of machine learning (ML)-based approaches to detect and diagnose CAD. A dataset of 918 instances from the UCI ML repository, comprising 11 typical risk factors and CAD predictors, was used for this investigation. The study deployed ML models in Google Colaboratory and PyCaret, testing their efficacy in diagnosing CAD. Our study provides a detailed overview of these ML methodologies, their strengths, and limitations, underscoring the potential of these algorithms to revolutionize CAD diagnosis and treatment. The overall goal of the study is to create a model that can predict the presence or chance of presence of CAD based on different parameters of the patient’s history. Findings include the showcased logistic regression model, which was proven to be particularly effective, with an area under curve of 0.88, indicating a high ability to differentiate between patients with and without CAD, and a successful ability to identify clinically key features of CAD such as the presence of exertional angina and chest pain. This study emphasizes the importance of further research in this field to establish ML as a cornerstone of modern healthcare diagnostics.

Keywords
Machine learning
Coronary artery disease
Diagnosis
Predictive modeling
Health informatics
Medical data analysis
Funding
None.
Conflict of interest
The authors declare that they have no competing interests.
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Global Translational Medicine, Electronic ISSN: 2811-0021 Print ISSN: 3060-8600, Published by AccScience Publishing
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