The intricate relationship between the brain and the heart extends far beyond traditional neural signaling; it is profoundly mediated by a dynamic, interconnected fluid network. "Cerebro-cardiac fluid circulation" represents a critical, emerging frontier that encompasses cerebral blood flow, the glymphatic clearance system, and neuro-immune cross-talk. Pulsatile cardiac function intrinsically drives cerebral hemodynamics, which in turn propels the glymphatic transport of metabolic waste and regulates the immune microenvironment across the blood-brain barrier. Disruptions in this delicate fluidic coupling are increasingly recognized as primary drivers in the pathogenesis of cardiovascular diseases, stroke, and neurodegenerative conditions.

This Special Issue seeks to unravel the complexities of this interconnected system by inviting original basic, translational, and clinical research. We aim to highlight studies investigating the mechanistic links between systemic blood flow alterations, glymphatic impairment, and neuroinflammation. Furthermore, this issue will spotlight cutting-edge medical technologies and novel methodologies designed to decode these complex fluidic interactions. We highly encourage interdisciplinary submissions that leverage advanced biomedical informatics, computational fluid dynamics, and artificial intelligence. Studies utilizing deep learning, foundation models, or the integration of multi-modal data—such as neuroimaging coupled with genomics and tabular biomarkers—are of particular interest to accurately map and predict fluid-driven pathologies.

By bridging traditional hemodynamic research with state-of-the-art computational tools, this Special Issue aims to identify novel diagnostic biomarkers and targeted therapeutic strategies. Ultimately, elucidating the cerebro-cardiac fluid network will pave the way for precision interventions to mitigate cognitive decline, Alzheimer's disease, and related neurovascular burdens.