AccScience Publishing / BH / Online First / DOI: 10.36922/bh.2065
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MINI-REVIEW

Therapeutic potential of mesenchymal stem cells and their mechanisms of regeneration for cardiac diseases

Merlin Sobia Poomani1 ,  Varshini Radhakrishnan1 ,  Senolin Bindhia James1 ,  Krishnaveni Muthan2 ,  Venkatesh Subramanian1*
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1 Department of Biotechnology, Manonmaniam Sundaranar University, Tirunelveli, Tamil Nadu, India
2 Department of Animal Science, Manonmaniam Sundaranar University, Tirunelveli, Tamil Nadu, India
Brain & Heart 2024, 2(1), 2065 https://doi.org/10.36922/bh.2065
Submitted: 18 October 2023 | Accepted: 30 November 2023 | Published: 13 February 2024
© 2024 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
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Abstract

Ischemic heart disease remains a major contributor to mortality and disability despite significant advancements in traditional treatments. This threat underscores the need for exploring innovative cell-based therapies. The analysis of various stem and progenitor cells’ capacity to promote heart regeneration has led to encouraging outcomes in preclinical and clinical experiments. Mesenchymal stem cells (MSCs) have demonstrated the ability to contribute to heart regeneration through several pathways, including differentiation from the mesoderm lineage, immunomodulatory characteristics, and paracrine actions. In addition, their accessibility, maintenance, and capacity to replenish endogenous stem cell niches render them appropriate for cutting-edge research. This review outlines the robust mechanism underpinning MSC-based heart regeneration, presents the potential therapeutic uses of MSCs for ischemic heart disease, and highlights some preclinical findings.

Keywords
Mesenchymal stem cells
Exosomes
Cardiac diseases
Clinical trials
Regeneration
Funding
None.
Conflict of interest
The authors declare that they have no competing interests.
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