In modern oncology, radiotherapy is seldom used as a standalone treatment. The column "Integrative Radiotherapy: Strategies & Synergy" is dedicated to the art and science of effectively combining radiation therapy with a full range of cancer care options. We focus on moving beyond isolated treatment methods to explore the powerful synergies that define contemporary practice. Each installment will provide critical analysis and practical guidance for creating effective multimodal treatment plans. Key topics will include the sequencing of chemotherapy and immunotherapy with radiation, the use of novel radiosensitizers, management of toxicities from combined modalities, and interpretation of data from pivotal trials that inform our integrative approaches. This column serves as an essential resource for radiation oncologists, medical oncologists, and all clinicians who are committed to developing cohesive, patient-centered treatment pathways that maximize efficacy while preserving quality of life.