On the occasion of its third anniversary, Advanced Neurology (AN) proudly presents this special issue, featuring a collection of original research articles and reviews authored by distinguished scientists, including members of our esteemed Editorial Board. This issue showcases the latest advancements in neurology and neuroscience, reflecting the state of the art in our understanding of the nervous system and its complexities. Over the past three years, we have strived to adapt to evolving research trends and publishing needs, maintaining our commitment to excellence and innovation. This special issue not only celebrates our journey but also underscores our dedication to advancing neurological science and fostering global collaboration. We invite you to explore this collection, which highlights the vibrant progress in the field and sets the stage for future discoveries.