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ORIGINAL RESEARCH ARTICLE

Signatures of neurological adverse events after vaccination

Darrell O. Ricke1* ,  Jessica Rose2
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1 Department of Research, Molecular BioInsights, Winchester, Massachusetts, United States of America
2 Independent Researcher, Ontario, Canada
Advanced Neurology 2024, 3(1), 2258 https://doi.org/10.36922/an.2258
Submitted: 16 November 2023 | Accepted: 15 February 2024 | Published: 12 March 2024
© 2024 by the Author (s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
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Abstract

There have been reports associated with the development of neurological adverse events (AEs) post-vaccination. Here, we retrospectively examine the Vaccine Adverse Events Reporting System (VAERS) database for neurological AEs reported following vaccination. Since VAERS is a passive reporting system, to minimize reporting bias and to reduce background events, this retrospective study examines both age-stratified AE reports made with onset within 24 h of immunization, and age-stratified AE reports regardless of timeframe from immunization. Immediate temporal onset data patterns for febrile convulsion, seizure, and syncope AEs were observed for multiple vaccines. For age-stratified AEs in infants up to 3 years of age, the following patterns of high association were observed: (i) Aphasia, autism spectrum disorder, and speech disorder were found to be highly associated with the measles, mumps, and rubella and hepatitis B (HepB) vaccines; (ii) febrile convulsion and syncope were found to be highly associated with the meningococcal group B vaccine; and (iii) seizures were found to be highly associated with diphtheria and tetanus toxoids and whole-cell pertussis (DTP) vaccines.

Keywords
Neurological diseases
Vaccines
COVID-19 vaccines
Febrile convulsion
Seizure
Syncope
Autism spectrum disorder
Funding
None.
Conflict of interest
The author declares they have no competing interests.
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Advanced Neurology, Electronic ISSN: 2810-9619 Print ISSN: 3060-8589, Published by AccScience Publishing
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