Human aspirations have consistently centered on reducing mental burdens, prolonging life, and mastering destiny, with science and technology serving as primary tools toward these goals. Artificial intelligence (AI), particularly through machine learning, offers powerful means of transforming data into knowledge and addressing complex biological challenges. At the same time, the human microbiome has emerged as a crucial determinant of health, longevity, and disease resistance. The microbiome, comprising over 38 trillion microorganisms–including bacteria, fungi, protozoa, and viruses–interacts dynamically with the human body. Its collective genetic material exceeds that of the human genome by hundreds of times, positioning it as an equally influential factor in shaping individual destiny. Unlike DNA, the microbiome is highly adaptable and can be reshaped in relatively short periods through diet, lifestyle, or medication. This adaptability creates opportunities for preventive and personalized medical interventions. To illustrate its importance, the microbiome can be conceptualized as the body’s “microbial pets.” These companions coexist as dining partners and life-long residents whose well-being directly influences human vitality. Like pets, they require proper care–particularly fiber-rich nutrition–and neglect can result in harmful consequences. This metaphor highlights the need to view microbial ecosystems not as passive inhabitants but as active partners in human health. By combining microbiome research with AI, it becomes possible to map these “microbial pets” with precision, uncover hidden interactions, and identify early indicators of disease. Such integration points toward a future where preventive, predictive, and personalized medicine fundamentally reshape human health and extend life expectancy.