Colorectal cancer remains a significant public health concern globally, necessitating ongoing research to enhance diagnostic accuracy and optimise management strategies. This Column explores cutting-edge advancements in colorectal cancer diagnosis and management comprehensively and highlights novel strategies for early detection, surveillance, and prevention of colorectal cancer. By gathering insights from leading experts and presenting the latest research findings, this Column aims to provide clinicians and researchers with valuable knowledge to enhance the diagnosis and management of colorectal cancer.