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CASE REPORT
Chemotherapy-induced ileus and gastrointestinal hemorrhage following therapy with BrECADD for Hodgkin lymphoma: A case report
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1 Department of Internal Medicine I., Centre for Oncology and Haematology, Vienna Healthcare Group, Ottakring, Vienna,
Austria
Tumor Discovery, 025180033 https://doi.org/10.36922/TD025180033
Received: 1 May 2025 | Revised: 12 June 2025 | Accepted: 2 July 2025 | Published online: 21 July 2025
© 2025 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
Abstract
A 62-year-old male with newly diagnosed advanced-stage Hodgkin lymphoma (HL) developed life-threatening gastrointestinal (GI) complications during brentuximab vedotin, etoposide, cyclophosphamide, doxorubicin, dacarbazine, and dexamethasone chemotherapy. He presented with chemotherapy-induced enteritis and jejunal ileus, followed by severe GI bleeding requiring two consecutive laparotomies and segmental jejunal resections. Histology revealed ulcerative jejunitis without signs of lymphoma infiltration. His medical course was further complicated by acute renal failure requiring dialysis. Although the patient temporarily stabilized with intensive care management, he subsequently developed Candida sepsis. At the time of submission, his outcome remains uncertain. This case underscores a rare but serious occurrence of GI toxicity associated with intensive chemotherapy for HL.
Keywords
Ileus
Enteritis
Hemorrhage
BrECADD
Hodgkin lymphoma
Funding
None.
Conflict of interest
The authors declare they have no competing interests.
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