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E-cadherin-positive and strong P53-positive acute erythroleukemia in an elderly man: A case report
Yasuhiro Kazuma1 ,
Yutaka Shimazu1,2 ,
Keisuke Shindo1 ,
Naoyuki Anzai1 ,
Miyako Kobayashi1 ,
Satoko Mibayashi3 ,
Shinsaku Imashuku1,4*
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1
Department of Hematology, Uji-Tokushukai Medical Center, Uji, Kyoto,
Japan
2
Department of Early Clinical Development, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto,
Japan
3
Department of Diagnostic Pathology, Uji-Tokushukai Medical Center, Uji, Kyoto,
Japan
4
Department of Laboratory Medicine, Uji-Tokushukai Medical Center, Uji, Kyoto,
Japan
Submitted: 26 March 2024 | Accepted: 12 June 2024 | Published: 4 September 2024
© 2024 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
Abstract
Acute erythroleukemia (FAB M6), a rare form of acute myeloid leukemia, consists of two subtypes: M6a-erythroid/myeloid leukemia and M6b-pure erythroid leukemia (PEL). The diagnosis of PEL is often difficult due to the negativity of classical erythroid cell markers. Recently, an epithelial calcium-dependent cell adhesion protein (E-cadherin) has been identified as a marker of immature erythroid precursors. Here, we report an elderly case of PEL in which E-cadherin positivity and strong P53 positivity were the key clues for diagnosis. The patient was treated with a daunomycin/Ara-C regimen followed by a venetoclax/azacitidine regimen but responded to neither treatment.
Keywords
Acute erythroleukemia
Pure erythroid leukemia
E-cadherin
P53
Funding
None.
Conflict of interest
The authors declare no conflicts of interest.
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