Receptors of advanced glycation end products in oral squamous cell carcinoma: A systematic review

¹ Department of Oral and Maxillofacial pathology, Saveetha Dental College and Hospitals, Saveetha Institute for Medical and Technical Sciences, Chennai, Tamil Nadu, India

Tumor Discovery 2023, 2(1), 244 https://doi.org/10.36922/td.244

Submitted: 2 November 2022 | Accepted: 27 January 2023 | Published: 10 February 2023

© 2023 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )

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Abstract

Oxidative stress markers have been shown to be elevated in oral squamous cell carcinomas; plays a crucial role in the build-up of advanced glycation end-receptors of advanced glycation end (AGE-RAGE) products; and has been shown to exacerbate cellular dysfunction, vascular change, apoptosis, and activate inflammatory pathways. The purpose of this study is to assess comprehensively the involvement of RAGE in oral squamous cell malignancies. The findings imply that these receptors and their associated ligands play a significant role in the growth and spread of the tumor, hence impacting the prognosis and life expectancy of the affected individual. This comprehensive review uncovers promising evidence for the clinical use of these molecules, such as RAGEs, in prognostic considerations or as molecular targets for therapy. The available literature shows a role for RAGE in invasion, migration, and angiogenesis in oral cancers. These preliminary findings are encouraging for the therapeutic use of these molecules for prognostic considerations or molecularly targeted therapy.

Keywords

Receptors of advanced glycation end products

Advanced glycation end products

Oral squamous cell carcinoma

Oral cancers

Funding

None.

Conflict of interest

The authors declare no conflicts of interest.

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