Millions of patients worldwide suffer from nonhealing wounds: an unappreciated epidemic that afflicts the vulnerable, poor, elderly, minority, and diabetic populations. The burgeoning specialty of wound care needs evidenced-based guidance on the treatment and prevention of nonhealing wounds and postoperative skin and tissue infections. This special edition, Innovations in Wound Healing, aims to highlight advances in the field including diagnostics, novel treatments and prevention strategies, consistent protocol design, standardized endpoints for clinical trials, guidance documents and the latest in interventions. We candidly invite and encourage researchers and clinicians to contribute to this special issue.