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Nanotherapies: A potent treatment for neurodegenerative diseases
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1 Department of Pharmaceutics, College of Pharmacy, Jinan University, Guangzhou, Guangdong,
China
Received: 2 September 2025 | Revised: 12 October 2025 | Accepted: 27 October 2025 | Published online: 14 November 2025
© 2025 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution -Noncommercial 4.0 International License (CC-by the license) ( https://creativecommons.org/licenses/by-nc/4.0/ )
Abstract
It is generally reported that neurodegenerative diseases, including Alzheimer’s disease and Parkinson’s disease, pose severe threats to global public health. Traditional therapies for neurodegenerative diseases exhibit low drug delivery efficiency due to the restrictive nature of the blood–brain barrier. Fortunately, nanomedicines can effectively overcome blood–brain barrier through mechanisms such as intercellular penetration and receptor targeting, which have advantages such as controlled release, reduced toxicity, and enhanced efficacy. In this paper, we summarize the latest research progress based on the types of nanomaterials, administration approach, and implications, with the aim of providing insights for optimizing the research and development of nanomedicines for neurodegenerative diseases.
Keywords
Nanotherapy
Neurodegenerative diseases
Drug delivery
Targeted delivery
Funding
This work was supported by the Natural Science Foundation of Guangdong Province under Grant No. 2025A1515010639.
Conflict of interest
The authors declare they have no competing interests.
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