AccScience Publishing / IJB / Volume 10 / Issue 3 / DOI: 10.36922/ijb.2056
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REVIEW

3D-bioprinted bone for regenerative medicine: Current concepts and future perspectives

Borbála Lovászi1,2,3 ,  Diána Szűcs1,2,3 ,  Tamás Monostori1,3 ,  Lajos Kemény1,3,4,5 ,  Zoltán Veréb1,3,4*
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1 Regenerative Medicine and Cellular Pharmacology Laboratory, Department of Dermatology and Allergology, University of Szeged, Szeged, Hungary
2 Doctoral School of Clinical Medicine, University of Szeged, Szeged, Hungary
3 Interdisciplinary Research Development and Innovation, Center of Excellence, University of Szeged, Szeged, Hungary
4 Research Institute of Translational Biomedicine, Department of Dermatology and Allergology, University of Szeged, Szeged, Hungary
5 Hungarian Centre of Excellence for Molecular Medicine-University of Szeged Skin Research Group (HCEMM-USZ Skin Research Group), University of Szeged, Szeged, Hungary
IJB 2024, 10(3), 2056 https://doi.org/10.36922/ijb.2056
Submitted: 17 October 2023 | Accepted: 21 February 2024 | Published: 12 June 2024
© 2024 by the Author(s).. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
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Abstract

The shortages in human tissue and organ donors have made clinical therapy relatively challenging. Therefore, research has been initiated over the last decades to develop artificial tissues and organs, particularly from cell and tissue cultures. Three-dimensional (3D) bioprinting is a recent technology capable of building structures for implantation, and these constructs closely resemble native tissues, such as skin, liver, connective tissues, and supportive tissues (bone and cartilage). In this review, we briefly introduce the structure, function, and development of bone tissues, followed by a detailed discussion on 3D bioprinting techniques, materials, and their recent advancements for clinical applications.

Keywords
Bone
3D bioprinting
Transplantation
Therapy
Clinical use
Regenerative medicine
Funding
This work was supported by GINOP_ PLUSZ-2.1.1-21-2022-00043 (co-financed by the European Union and the European Regional Development Fund) and the National Research, Development, and Innovation Office (NKFIH PD 132570 to ZV). ZV is a recipient of the János Bolyai Research Scholarship of the Hungarian Academy of Sciences (BO/00190/20/5) and the NPP-22- 5 Bolyai+ Fellowship (NKP-22-5-SZTE-319), financed by the New National Excellence Program of the Hungarian Ministry of Innovation and Technology from the National Research Development and Innovation Fund. The projects (TKP2021-EGA-28 and TKP2021-EGA-32) were funded by the Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund, financed under the TKP2021-EGA funding scheme.
Conflict of interest
The authors declare no conflicts of interest.
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International Journal of Bioprinting, Electronic ISSN: 2424-8002 Print ISSN: 2424-7723, Published by AccScience Publishing
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