News and Announcements
MINI-REVIEW
Autogenous dentin as a graft material for alveolar ridge preservation in dentistry: Definition and clinical application
Carmen López-Carriches*1 ,
Ana González-González1 ,
Ricardo Bahram Taheri1 ,
Cristina Madrigal-Martínez-Pereda1
Show Less
1 Department of Dental Clinical Specialties, School of Dentistry, Complutense University of Madrid, Madrid,
Spain
Global Translational Medicine, 025110025 https://doi.org/10.36922/GTM025110025
Received: 14 March 2025 | Revised: 5 January 2026 | Accepted: 29 January 2026 | Published online: 12 May 2026
© 2026 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
Abstract
Adequate bone volume is essential for implant placement, and in many cases, can only be achieved through bone grafting. However, impaction of lower third molars can cause bone lysis in the distal alveolar area of the second molar. Hence, this review evaluates the effectiveness of autogenous dentin in alveolar preservation and bone augmentation in implant surgery, as well as its role in preventing the development of bone defects and subsequent periodontal pocket formation after lower third molar extraction. A bibliographic review was conducted across electronic databases, including PubMed/MEDLINE and the Cochrane Library Plus. Multiple studies concluded that autogenous dentin is suitable for bone regeneration. Autogenous dentin enhances bone regeneration in the extraction socket, facilitates bone volume augmentation in implant surgery, and prevents periodontal pocket formation distal to the second molar following lower third molar extraction.
Keywords
Autogenous dentin
Lower third molar
Tooth transformer
Socket preservation
Maxillary sinus augmentation
Dental implants
Funding
None.
Conflict of interest
The authors declare that there are no conflicts of interest.
References
- Zhang Y, Chen X, Zhou Z, et al. Effects of Impacted Lower Third Molar Extraction on Periodontal Tissue of the Adjacent Second Molar. TCRM. 2021; 17:235-247. doi: 10.2147/tcrm.s298147
- Low SH, Lu SL, Lu HK. Evidence-based clinical decision making for the management of patients with periodontal osseous defect after impacted third molar extraction: A systematic review and meta-analysis. J Dent Sci. 2021;16(1):71-84. doi: 10.1016/j.jds.2020.06.018
- Kilinc A, Ataol M. Effects of collagen membrane on bone level and periodontal status of adjacent tooth after third molar surgery: a randomized controlled trial. Head Face Med. 2023;19(1):13. doi: 10.1186/s13005-023-00351-8
- de Oliveira G, Miziara M, Silva E da, Ferreira E, Biulchi A, Alves J. Enhanced bone formation during healing process of tooth sockets filled with demineralized human dentine matrix. Aust Dent J. 2013;58(3):326-332. doi: 10.1111/adj.12088
- Janjua OS, Qureshi SM, Shaikh MS, et al. Autogenous Tooth Bone Grafts for Repair and Regeneration of Maxillofacial Defects: A Narrative Review. Int J Env Res Public Health. 2022;19(6):3690. doi: 10.3390/ijerph19063690
- Gual-Vaques P, Polis-Yanes C, Estrugo-Devesa A, Ayuso- Montero R, Mari-Roig A, Lopez-Lopez J. Autogenous teeth used for bone grafting: A systematic review. Med. Oral. 2017,23(1):e112-e119. doi: 10.4317/medoral.22197
- Inchingolo AM, Patano A, Di Pede C, et al. Autologous Tooth Graft: Innovative Biomaterial for Bone Regeneration. Tooth Transformer® and the Role of Microbiota in Regenerative Dentistry. A Systematic Review. J Funct Biomater. 2023;14(3):132. doi: 10.3390/jfb14030132
- Inchingolo AM, Marinelli G, Inchingolo F, et al. Autologous Tooth-Derived Biomaterials in Alveolar Bone Regeneration: A Systematic Review of Clinical Outcomes and Histological Evidence. J Funct Biomater. 2025;16(10):367. doi: 10.3390/jfb16100367
- Minetti E, Gianfreda F, Palermo A, Bollero P. Autogenous Dentin Particulate Graft for Alveolar Ridge Augmentation with and without Use of Collagen Membrane: Preliminary Histological Analysis on Humans. Materials. 2022;15(12):4319. doi: 10.3390/ma15124319
- Sun H, Yin X, Yang C, Kuang H, Luo W. Advances in autogenous dentin matrix graft as a promising biomaterial for guided bone regeneration in maxillofacial region: A review. Medicine. 2024;103(34):e39422. doi: 10.1097/MD.0000000000039422
- Dipalma G, Inchingolo AD, Calò F, et al. Eighty-Four- Month Clinical Outcomes of Autologous Dentin Graft Using Tooth Transformer® and Concentrated Growth Factors in Maxillary Atrophy: A Retrospective Study of 31 Patients. J Funct Biomater. 2025;16(10):357. doi: 10.3390/jfb16100357
- Alrmali A, Saleh MHA, Mazzocco J, Zimmer JM, Testori T, Wang HL. Auto-dentin platelet-rich fibrin matrix is an alternative biomaterial for different augmentation procedures: A retrospective case series report. Clin Exp Dent Res. 2023;9(6):993-1004. doi: 10.1002/cre2.808
- Minetti E, Taschieri S, Berardini M, Corbella S. New Classification of Autologous Tooth-Derived Grafting Materials: Fundamental Concepts. Int J Dent. 2025;2025(1):6646405. doi: 10.1155/ijod/6646405
- Sivaraman K, Rajwar E, Chopra A, et al. How effective is dentin autograft for socket preservation and implant site preparation: A systematic review protocol. F1000Res. 2024;13:204. doi: 10.12688/f1000research.144522.2
- Jalůvka P, Šrubař J, Starosta M. Autogenous dentin for socket preservation: a narrative review of clinical outcomes compared to spontaneous healing. Front Dent Med. 2025;6:1714903. doi: 10.3389/fdmed.2025.1714903
- Ramanauskaite A, Sahin D, Sader R, Becker J, Schwarz F. Efficacy of autogenous teeth for the reconstruction of alveolar ridge deficiencies: a systematic review. Clin Oral Invest. 2019;23(12):4263-4287. doi: 10.1007/s00784-019-02869-1
- Kuperschlag A, Keršytė G, Kurtzman GM, Horowitz RA. Autogenous Dentin Grafting of Osseous Defects Distal to Mandibular Second Molars After Extraction of Impacted Third Molars. Compend Contin Educ Dent. 2020;41(2):76- 82; quiz 83. Available from: https://pubmed.ncbi.nlm.nih. gov/32017585/ [Last accessed on].
- Kim Y, Ku JK, Um IW, Seok H, Leem DH. Impact of Autogenous Demineralized Dentin Matrix on Mandibular Second Molar after Third Molar Extraction: Retrospective Study. J Funct Biomater. 2022;14(1):4. doi: 10.3390/jfb14010004
- Pohl V, Schuh C, Fischer MB, Haas R. A New Method Using Autogenous Impacted Third Molars for Sinus Augmentation to Enhance Implant Treatment: Case Series with Preliminary Results of an Open, Prospective Longitudinal Study. Int J Oral Maxillofac Implants. 2016;31(3):622-30. doi: 10.11607/jomi.4172
- Feng Y, Zhao R, Li J, Yuan Z, Xu X, Gong J. Efficacy of autogenous particulated dentin graft for alveolar ridge preservation: A systematic review and meta-analysis of randomized controlled trials. Medicine. 2023;102(48):e36391. doi: 10.1097/MD.0000000000036391