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MINI-REVIEW
Mass spectrometry-driven advances in blood-based biomarkers for Alzheimer’s disease: A mini-review
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1 Anhui Nova MS Biotechnology Co, Ltd, Hefei, Anhui,
China
2 Department of Geriatrics, The Second Affiliated Hospital of Nanjing Medical University, Nanjing,
China
Global Translational Medicine, 025250050 https://doi.org/10.36922/GTM025250050
Received: 5 May 2025 | Revised: 2 June 2025 | Accepted: 24 June 2025 | Published online: 22 September 2025
© 2025 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
Abstract
The core pathological characteristics of Alzheimer’s disease (AD) are characterized by the deposition of β-amyloid plaques and the formation of tau protein neurofibrillary tangles. Clinical diagnosis predominantly relies on cerebrospinal fluid analysis or positron emission tomography. However, these methods are associated with the risks of invasive procedures and significant cost constraints. Mass spectrometry, with its high sensitivity (reaching the femtogram level) and capability for multiplex detection, facilitates not only the precise quantification of AD biomarkers in blood but also offers a cost-effective solution. This review systematically elucidates the advancements in the clinical application of mass spectrometry technology for risk assessment, early diagnosis, and therapeutic monitoring of AD. It also highlights recent breakthroughs in identifying novel blood biomarkers using mass spectrometry technology and a multi-omics integration strategy.
Keywords
Mass spectrometry
Alzheimer’s disease
Blood-based biomarkers
Amyloid β-protein
p-Tau
Funding
This work was supported by The Key Program of Jiangsu Geriatric Health Research (grant number: BK20242002).
Conflict of interest
The authors declare that they have no competing interests.
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