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REVIEW ARTICLE

Perspectives on the small ribonucleic acid drugs for pancreatic cancer

Qingqing Zhou1 ,  Guoan Shen2 ,  Huaying Li2 ,  Haimei Chen1 ,  Chang Liu1*
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1 Department of Bioinformatics, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
2 Department of Research & Development, Beijing Young Lingzhi Health Industry Research Institute Co., Ltd, Beijing, China
Global Translational Medicine, 8247 https://doi.org/10.36922/gtm.8247
Submitted: 27 December 2024 | Revised: 26 February 2025 | Accepted: 6 March 2025 | Published: 19 March 2025
© 2025 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
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Abstract

Pancreatic cancer (PC) remains one of the most lethal forms of cancer. Unfortunately, existing drugs for PC would cause significant side effects, and the tumor may develop resistance to these treatments. Therefore, there is an urgent need to develop new drugs to provide more treatment options for PC patients. Compared to traditional protein-targeted and DNA-based drugs, ribonucleic acid (RNA)-based therapies have gained significant attention in recent years due to their unique physicochemical and physiological properties. Various strategies have been developed to enhance the metabolic stability and intracellular delivery of small RNA drugs, making them a key focus in cancer drug development in recent years. To explore the therapeutic potential of small RNA drugs in PC, an overview of the status of small RNA drug development is provided, including 17 approved small RNA drugs and 43 small RNA drug candidates in clinical trials. In addition, genetic factors involved in PC progression are examined, identifying 17 protein-coding genes and 15 microRNA genes. Finally, six strategies for developing small RNA drugs for PC are discussed.

Keywords
Small ribonucleic acid drugs
Pancreatic cancer
Drug target
Funding
The study was supported by the National Natural Science Foundation of China (81872966), the CAMS Innovation Fund for Medical Sciences (CIFMS) (2021-1-I2M-022), the Provincial Special Project for Construction of Innovation Demonstration Area at Chenzhou City under the National Sustainable Development Plan (2023sfq04), and the National Science and Technology Fundamental Resources Investigation Program of China (2018FY100705). The funders had no role in the study design, data collection, analysis, publication decision, or manuscript preparation.
Conflict of interest
The authors declare they have no competing interests.
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Global Translational Medicine, Electronic ISSN: 2811-0021 Print ISSN: 3060-8600, Published by AccScience Publishing
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