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REVIEW

Comparative analysis of immune responses in humans infected with Alpha, Delta, and Omicron strains of SARS-CoV-2

Mihieka Bose1,2 ,  Chayan Munshi1*
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1 1 Ethopilia Research Foundation, Santiniketan, India
2 Department of Zoology, Visva Bharati University, Santiniketan, India
Global Translational Medicine 2024, 3(1), 2228 https://doi.org/10.36922/gtm.2228
Submitted: 10 November 2023 | Accepted: 25 December 2023 | Published: 19 March 2024
© 2024 by the Author (s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
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Abstract

The COVID-19 pandemic outbreak has profoundly challenged global public health over the last couple of years. Throughout this period, numerous mutant strains of SARS-CoV-2 have emerged, presenting diverse pathophysiology and immune response challenges for infected individuals. Among these, variant of concern strains, including Alpha (B.1.1.7), Delta (B.1.617.2), and Omicron (B.1.1.529), has garnered the most significant attention for their role in causing epidemiological dynamics, ultimately leading to elevated infectivity and significant mortality rates. This review aims to provide a comparative analysis of the immune-pathophysiological mechanisms associated with these aforementioned strains of SARS-CoV-2.

Keywords
SARS-CoV-2
Immune response
Pandemic
Funding
None.
Conflict of interest
The authors declare no conflicts of interest
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