AccScience Publishing / GTM / Online First / DOI: 10.36922/gtm.2208
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Mitochondrial involvement in ferroptotic cell death

Chayan Munshi1* ,  Tithi Paul1,2 ,  Kalpesh Jas1,2† ,  Mihieka Bose1,2† ,  Shelley Bhattacharya2
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1 Ethophilia Research Foundation, Santiniketan, India
2 Department of Zoology, Visva Bharati University, Santiniketan, India
Global Translational Medicine 2024, 3(2), 2208 https://doi.org/10.36922/gtm.2208
Submitted: 8 November 2023 | Accepted: 4 January 2024 | Published: 18 March 2024
© 2024 by the Author (s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
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Abstract

Ferroptosis is a regulated cell death pathophysiologically associated with the depletion of the antioxidant system due to iron overload, which results in excess lipid peroxidation. Mitochondria are crucial organelles known for their prominent involvement in various cellular metabolic activities and cell death processes. While our understanding of ferroptotic signaling pathways is advancing, further investigation into the intricate relationship between mitochondrial bio-process and this mode of cell death is necessary to identify effective biomedical therapeutic options targeting this organelle. However, the direct involvement of mitochondria in ferroptosis has remained a topic of debate due to the limited availability of concrete information to date. This review aims to elucidate the pathophysiological perspectives of mitochondria during ferroptotic cell death.

Keywords
Ferroptosis
Mitochondria
Cell death
Funding
None.
Conflict of interest
The authors declare no conflicts of interest.
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Global Translational Medicine, Electronic ISSN: 2811-0021 Print ISSN: 3060-8600, Published by AccScience Publishing
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