Journal Browser
Volume | Year
Issue
Search
News and Announcements
View All

Pathogenesis and therapeutics of primary liver cancer: the basic, translational and clinical perspectives

Submission Deadline: 18 December 2025
Special Issue Editor
Daniel Wai-Hung Ho
Department of Pathology, School of Clinical Medicine, The University of Hong Kong, Hong Kong, China
Interests:

Genomic; Transcriptomic; Liver cancer; Liquid biopsy; Bioinformatics

Profile:

 

His research focuses are bioinformatics analyses on high-throughput omics data and computational analysis tools development. He have particular interests on genomics studies of hepatocellular carcinoma (HCC) through the application of next generation sequencing, large-scale screening, liquid biopsy, and single-cell and spatial transcriptomics. He is also involved in multidisciplinary and integrative studies to investigate and understand the molecular mechanism of hepatocarcinogenesis, metastasis and treatment response of HCC.

Special Issue Information

Primary liver cancer is a leading fatal malignancy. It is known to have a high degree of intra- and intertumoral heterogeneities, leading to frequent treatment resistance and disease recurrence. There is an increasing number of treatment options but their performance remains sub-optimal. The hepatocarcinogenesis process of liver cancer is complex and involves the endeavor of malignant and immune components. There is an accumulation of various genetic and epigenetic alterations that pinpoint key signaling pathways or biological processes. With the emergence of different sequencing-based strategies, high-throughput screening platforms as well as computational algorithms, we are able to delineate the underlying molecular and cellular landscapes in primary liver cancer to a better extent. This special issue will focus on different niche areas that cover the individual aspects (basic, translational and clinical) of liver cancer research.

 

This special issue will include the following topics:

- transcriptomic landscape

- genomic landscape

- epigenetic landscape

- cellular landscape

- tumor heterogeneity

- single-cell and spatial analysis

- tumor microenvironment

- cancer stem cell

- animal models

- liquid biopsy

- biomarker discovery

- latest treatment (chemotherapy, targeted therapy and immunotherapy)

Keywords
Liver cancer
HCC
HBV
MASLD
MASH
cancer genomics
Back to top
Eurasian Journal of Medicine and Oncology, Electronic ISSN: 2587-196X Print ISSN: 2587-2400, Published by AccScience Publishing