AccScience Publishing / ARNM / Volume 1 / Issue 2 / DOI: 10.36922/arnm.0963
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CASE REPORT

Evaluating the efficacy of immunochemoradiotherapy in malignant pleural mesothelioma and distinguishing benign from malignant lymph nodes using 18F-FDG PET/CT and 18F-FAPI-04 PET/CT imaging: A case report

Mengye Peng1 Menglu Wang1 Ying Zhang1 Tingting Wu1 Kezheng Wang1*
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1 Department of PET-CT, Harbin Medical University Cancer Hospital, Harbin, China
Submitted: 19 May 2023 | Accepted: 4 September 2023 | Published: 7 November 2023
© 2023 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
Abstract

In this paper, we report a case of pleural mesothelioma, imaged employing 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT), and 18F-fibroblast activating protein inhibitor (FAPI)-04 PET/CT. The diagnosis of pleural mesothelioma was confirmed by histopathologically examining the thoracoscopic biopsy. The patient underwent an 18F-FDG PET/CT before immunochemoradiotherapy, followed by an 18F-FAPI-04 imaging 3 months after treatment. The changes in focal anatomy, morphology, and metabolic biology observed between the two distinct PET/CT imaging modalities can aid in distinguishing benign and malignant lymph nodes and assessing treatment efficacy. This case highlights the diagnostic utility of 18F-FDG PET/C in pleural mesothelioma and suggests that 18F-FAPI-04 PET/CT may serve as an effective tool for evaluating the outcomes of immunochemotherapy. Moreover, the combined application of 18F-FDG PET/CT and 18F-FAPI-04 PET/CT holds promise for the differentiation of benign and malignant lymph nodes.

Keywords
18F-fluorodeoxyglucose
Fibroblast activation protein inhibitor
Malignant mesothelioma
Positron emission tomography/computed tomography
Immunochemoradiotherapy
Funding
National Natural Science Foundation of China General Projects
Provincial Key Research and Development Program of Heilongjiang Province
Postdoctoral Special Scientific Research Grant of Heilongjiang Provincial Government
Distinguished Young Scientist Funding of Harbin Medical University Affiliated Tumor Hospital
Key Project of the Climbing Funding of the National Cancer Center
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Conflict of interest
The authors report no conflict of interest in this paper.
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Advances in Radiotherapy & Nuclear Medicine, Electronic ISSN: 2972-4392 Published by AccScience Publishing