AccScience Publishing / ARNM / Volume 0 / Issue 0 / DOI: 10.36922/arnm.0824
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A case of primary pulmonary follicular dendritic cell sarcoma

Min Yang1 Hongcheng Zhong2 Xinghua He3 Hongjun Jin1*
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1 Guangdong Provincial Engineering Research Center of Molecular Imaging, the Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province 519000, China
2 Thoracic Surgery Department, the Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province 519000, China
3 Nuclear Medicine Department, the Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province 519000, China
Submitted: 24 April 2023 | Accepted: 29 June 2023 | Published: 13 July 2023
© 2023 by the Author(s). Licensee AccScience Publishing, Singapore. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( )

Here, we report a 66-year-old woman who presented with an irregular and lobulated pulmonary mass in the apical segment of the right superior lobe with an enlarged mediastinal lymph node. Abdominal computed tomography (CT), brain magnetic resonance imaging, and fluorine-18 fluorodeoxyglucose positron emission tomography/CT scans showed no extrapulmonary distant metastases. The patient underwent surgical sleeve resection of the right superior lobe with systematic hilar and mediastinal lymph node dissection. Post-operative histopathology, including hematoxylin and eosin staining, immunohistochemistry, and Epstein–Barr virus in situ hybridization, suggested primary pulmonary follicular dendritic cell sarcoma (FDCS). A follow-up plain chest CT indicated recurrence with multiple metastases of the liver, ribs, and mediastinal lymph nodes 1 year after surgery. The patient declined further therapy and was lost follow-up. In this case, FDCS located in the lung was unusual and rare. Corresponding imaging and histopathological features have enhanced our understanding of this disease. Meanwhile, it is necessary to include this tumor as a differential diagnosis of lung tumors and pay particular attention to the possibility of post-operative recurrence and metastasis. Moreover, considering the heterogeneity of FDCS, it is essential to identify the biological or imaging features that can reflect or predict the high risk of tumor recurrence and metastasis. A corresponding post-operative examination is also necessary to determine if any lesions remain.

Pulmonary follicular dendritic cell sarcoma
Lung cancer
Positron emission tomography/computed tomography
Clinical research IIT project of the Fifth Affiliated Hospital, Sun Yat-sen University
National Natural Science Foundation of China
National Key R&D Program of China
Guangdong Provincial Basic and Applied Basic Research Fund Provincial Enterprise Joint Fund
Starting Fund from the Fifth Affiliated Hospital, Sun Yat-sen University
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Conflict of interest
The authors declare that they have no competing interests.
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Advances in Radiotherapy & Nuclear Medicine, Electronic ISSN: 2972-4392 Print ISSN: TBA, Published by AccScience Publishing