1. Department of Neurology, The First Affiliated Hospital of USTC, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, Hefei National Research Center for Physical Sciences at the Microscale, University of Science and Technology of China, China;
2. Neurodegenerative Disorder Research Center, Anhui Province Key Laboratory of Biomedical Aging Research, University of Science and Technology of China, China;
3. CAS Key Laboratory of Brain Function and Disease, University of Science and Technology of China, China;
4. Biomedical Sciences and Health Laboratory of Anhui Province, University of Science and Technology of China, ChinaBrain aging and neurodegenerative diseases
Alzheimer’s disease (AD) is entering a new era shaped by biomarker-guided diagnosis, earlier detection, and the emergence of disease-modifying therapies. Yet major challenges remain, including biological heterogeneity, incomplete understanding of disease mechanisms, limited therapeutic responsiveness, and the need for more precise translational frameworks. This Special Issue aims to provide an updated and multidisciplinary view of AD across the full spectrum from basic discovery to clinical application. We welcome contributions addressing molecular and cellular mechanisms, neuroimmune and glial regulation, synaptic and circuit dysfunction, blood- and imaging-based biomarkers, risk stratification, early diagnosis, therapeutic development, and real-world challenges in treatment implementation. Reviews, mini-reviews, perspectives, and original studies that advance mechanistic insight, improve clinical precision, or bridge experimental and human research will be particularly encouraged.