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Treatment of Parkinson’s disease with piribedil: Suggestions for clinical practices

Cheng Jie Mao1 ,  Chan Piu2 ,  Li Rong Jin3 ,  Li Juan Wang4 ,  Olivier Rascol5* ,  Chun Feng Liu1*
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1 Department of Neurology, The Second Affiliated Hospital of Soochow University, Suzhou 215000, Jiangsu, China
2 Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing 100053, China
3 Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai 200032, China
4 Department of Neurology, Guangdong Provincial Peoples’ Hospital, Guangzhou 510080, Guangdong, China
5 Clinical Investigation Center CIC1436, Departments of Clinical Pharmacology and Neurosciences, NS-Park/FCRIN network and NeuroToul Center of Excellence for Neurodegeneration, INSERM, University Hospital of Toulouse and University of Toulouse, Toulouse, France
Advanced Neurology 2023, 2(1), 290 https://doi.org/10.36922/an.290
Submitted: 14 December 2022 | Accepted: 16 January 2023 | Published: 10 February 2023
© 2023 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
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Abstract

With rapidly growing rates of prevalence, disability, and mortality, Parkinson’s disease (PD) has become a global healthcare burden. Increasing elderly population increases the incidence of neurodegenerative diseases in China. Hence, PD poses a huge burden to Chinese economic and healthcare system. PD is a movement disorder that affects the motor and nonmotor functions. Dopamine agonists are used in the management of PD. Piribedil is an antiparkinsonian drug and piperazine derivative, which acts as D2/D3 receptor agonist. Piribedil is one of the non-ergot dopamine receptor (DR) agonists and has been used in China for many years as monotherapy or in combination with levodopa. In this paper, we present a review of clinical application of piribedil, management of adverse events, and drug interactions, and discuss the results of clinical trials of piribedil on motor and non-motor symptoms of PD.

Keywords
Neurodegenerative disease
Levodopa
Dopamine receptor
Non-ergot dopamine receptor agonists
α2-adrenoreceptor
Dyskinesia
Hypotension orthostatic
Funding
None.
Conflict of interest
The authors declare no financial or other conflicts of interest.
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