AccScience Publishing / AN / Online First / DOI: 10.36922/an.1394
Submit to AN
Cite this article
107
Download
1607
Views
Journal Browser
Volume | Year
Issue
Search
Forthcoming Issue
Current Issue
View All
News and Announcements
View All
ORIGINAL RESEARCH ARTICLE

Estimated glomerular filtration rate and serum neurofilament light chain: Insight from National Health and Nutrition Examination Survey

Jiangwen Liu1*
Show Less
1 Department of Cardiology, 928 Hospital of Joint Logistics Support Force of PLA, Haikou, 571100, Hainan, China
Advanced Neurology 2023, 2(3), 1394 https://doi.org/10.36922/an.1394
Submitted: 26 July 2023 | Accepted: 14 September 2023 | Published: 27 September 2023
© 2023 by the Authors (s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
Download PDF
Cite
XML
Abstract

The neurofilament light chain is a protein biomarker associated with neurodegenerative diseases. Neurofilament light chain levels may increase as kidney function declines due to reduced clearance. However, the relationship between estimated glomerular filtration rate (eGFR) and serum neurofilament light chain (sNfL) has not been extensively studied. Therefore, the objective of this study was to examine the association between eGFR and sNfL levels. Health survey data from 2071 eligible participants in the National Health and Nutrition Examination Survey (NHANES) were used in three multivariate-adjusted weighted linear regression models to analyze the correlation between eGFR and sNfL. Subsequently, segmental linear regression analysis was employed to determine the inflection point of eGFR. Finally, through subgroup analysis, we aimed to assess the impact of all covariates on the association between eGFR and sNfL. According to our results, sNfL levels decreased as eGFR increased. The segmental linear regression model analysis identified an inflection point at 59.9. When eGFR reached 59.9 or exceeded it, each unit increase in eGFR was associated with a 1 pg/mL decrease in sNfL (β = −0.1, P = 0.01). Furthermore, subgroup analysis revealed that hypertension exhibited a significant interaction with the association between eGFR and sNfL (P = 0.01). These findings suggest that eGFR holds promise as a potential marker for neurodegenerative disorders, and hypertension could affect this association to some extent. Moreover, these results could have significant implications for the early detection and prevention of neurodegenerative diseases in patients with kidney disease. However, further research is needed to corroborate these results and elucidate the underlying mechanisms.

Keywords
Estimated glomerular filtration rate
Serum neurofilament light chain
Kidney
National Health and Nutrition Examination Survey
Funding
None.
Conflict of interest
The author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
References
  1. Lidberg KA, Muthusamy S, Adil M, et al., 2022, Serum protein exposure activates a core regulatory program driving human proximal tubule injury. J Am Soc Nephrol, 33: 949–965. https://doi.org/10.1681/ASN.2021060751

 

  1. Proulx ST, Engelhardt B, 2022, Central nervous system zoning: How brain barriers establish subdivisions for CNS immune privilege and immune surveillance. J Intern Med, 292: 47–67. https://doi.org/10.1111/joim.13469

 

  1. Wang M, Ding D, Zhao Q, et al., 2021, Kidney function and dementia risk in community-dwelling older adults: The Shanghai Aging Study. Alzheimers Res Ther, 13: 21. https://doi.org/10.1186/s13195-020-00729-9

 

  1. Steinacker P, Anderl-Straub S, Diehl-Schmid J, et al., 2018, Serum neurofilament light chain in behavioral variant frontotemporal dementia. Neurology, 91: e1390–e1401. https://doi.org/10.1212/WNL.0000000000006318

 

  1. Tang R, Panizzon MS, Elman JA, et al., 2022, Association of neurofilament light chain with renal function: Mechanisms and clinical implications. Alzheimers Res Ther, 14: 189. https://doi.org/10.1186/s13195-022-01134-0

 

  1. Breeze CE, Batorsky A, Lee MK, et al., 2021, Epigenome-wide association study of kidney function identifies trans-ethnic and ethnic-specific loci. Genome Med, 13: 74. https://doi.org/10.1186/s13073-021-00877-z

 

  1. Lang J, Scherzer R, Tien PC, et al., 2014, Serum albumin and kidney function decline in HIV-infected women. Am J Kidney Dis, 64: 584–591. https://doi.org/10.1053/j.ajkd.2014.05.015

 

  1. Ladang A, Kovacs S, Lengelé L, et al., 2022, Neurofilament light chain concentration in an aging population. Aging Clin Exp Res, 34: 331–339. https://doi.org/10.1007/s40520-021-02054-z

 

  1. Revendova KZ, Zeman D, Bunganic R, et al., 2022, Serum neurofilament levels in patients with multiple sclerosis: A comparison of SIMOA and high sensitivity ELISA assays and contributing factors to ELISA levels. Mult Scler Relat Disord, 67: 104177. https://doi.org/10.1016/j.msard.2022.104177

 

  1. Rebelos E, Rissanen E, Bucci M, et al., 2022, Circulating neurofilament is linked with morbid obesity, renal function, and brain density. Sci Rep, 12: 7841. https://doi.org/10.1038/s41598-022-11557-2

 

  1. Zhao L, Sun Y, Cao R, et al., 2022, Non-linear association between composite dietary antioxidant index and depression. Front Public Health, 10: 988727. https://doi.org/10.3389/fpubh.2022.988727

 

  1. Levey AS, Stevens LA, Schmid CH, et al., 2009, A new equation to estimate glomerular filtration rate. Ann Intern Med, 150: 604–612. https://doi.org/10.7326/0003-4819-150-9-200905050-00006

 

  1. Kidney Disease: Improving Global Outcomes (KDIGO) Glomerular Diseases Work Group. 2021, KDIGO 2021 clinical practice guideline for the management of glomerular diseases. Kidney Int, 100: S1–S276. https://doi.org/10.1016/j.kint.2021.05.021

 

  1. Grundy SM, Cleeman JI, Daniels SR, et al., 2005, Diagnosis and management of the metabolic syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation, 112: 2735–2752. https://doi.org/10.1161/CIRCULATIONAHA.105.169404

 

  1. Mahemuti N, Jing X, Zhang N, et al., 2023, Association between systemic immunity-inflammation index and hyperlipidemia: A population-based study from the NHANES (2015-2020). Nutrients, 15: 1177. https://doi.org/10.3390/nu15051177

 

  1. Fan H, Zhou J, Huang Y, et al., 2022, A proinflammatory diet is associated with higher risk of peripheral artery disease. Nutrients, 14: 3490. https://doi.org/10.3390/nu14173490

 

  1. Polymeris AA, Helfenstein F, Benkert P, et al., 2022, Renal function and body mass index contribute to serum neurofilament light chain levels in elderly patients with atrial fibrillation. Front Neurosci, 16: 819010. https://doi.org/10.3389/fnins.2022.819010

 

  1. Garofalo C, Borrelli S, Pacilio M, et al., 2016, Hypertension and prehypertension and prediction of development of decreased estimated gfr in the general population: A meta-analysis of cohort studies. Am J Kidney Dis, 67: 89–97. https://doi.org/10.1053/j.ajkd.2015.08.027

 

  1. Yu Z, Rebholz CM, Wong E, et al., 2019, Association between hypertension and kidney function decline: The atherosclerosis risk in communities (ARIC) study. Am J Kidney Dis, 74: 310–319. https://doi.org/10.1053/j.ajkd.2019.02.015

 

  1. Siller N, Kuhle J, Muthuraman M, et al., 2019, Serum neurofilament light chain is a biomarker of acute and chronic neuronal damage in early multiple sclerosis. Mult Scler, 25: 678–686. https://doi.org/10.1177/1352458518765666

 

  1. Benkert P, Meier S, Schaedelin S, et al., 2022, Serum neurofilament light chain for individual prognostication of disease activity in people with multiple sclerosis: A retrospective modelling and validation study. Lancet Neurol, 21: 246–257. https://doi.org/10.1016/S1474-4422(22)00009-6

 

  1. Bhat SA, Goel R, Shukla R, et al., 2017, Platelet CD40L induces activation of astrocytes and microglia in hypertension. Brain Behav Immun, 59: 173–189. https://doi.org/10.1016/j.bbi.2016.09.021

 

  1. Rosenthal C, Wolf S, Weber-Carstens S, et al., 2012, Intracranial hypertension-therapeutic options. Anasthesiol Intensivmed Notfallmed Schmerzther, 47: 30–38; quiz 39. https://doi.org/10.1055/s-0032-1301379

 

  1. Beier D, Korsbæk JJ, Madsen JS, et al., 2020, Neurofilament light chain as biomarker in idiopathic intracranial hypertension. Cephalalgia, 40: 1346–1354. https://doi.org/10.1177/0333102420944866

 

  1. Engel S, Halcour J, Ellwardt E, et al., 2023, Elevated neurofilament light chain CSF/serum ratio indicates impaired CSF outflow in idiopathic intracranial hypertension. Fluids Barriers CNS, 20: 3. https://doi.org/10.1186/s12987-022-00403-2

 

  1. Koini M, Pirpamer L, Hofer E, et al., 2021, Factors influencing serum neurofilament light chain levels in normal aging. Aging (Albany NY), 13: 25729–25738. https://doi.org/10.18632/aging.203790

 

  1. Ciardullo S, Muraca E, Bianconi E, et al., 2023, Diabetes mellitus is associated with higher serum neurofilament light chain levels in the general US population. J Clin Endocrinol Metab, 108: 361–367. https://doi.org/10.1210/clinem/dgac580

 

  1. Maalmi H, Strom A, Petrera A, et al., 2023, Serum neurofilament light chain: A novel biomarker for early diabetic sensorimotor polyneuropathy. Diabetologia, 66: 579–589. https://doi.org/10.1007/s00125-022-05846-8

 

  1. Kohlhase K, Frank F, Wilmes C, et al., 2023, Brain-specific biomarkers in urine as a non-invasive approach to monitor neuronal and glial damage. Eur J Neurol, 30: 729–740. https://doi.org/10.1111/ene.15641
Share
Back to top
Advanced Neurology, Electronic ISSN: 2810-9619 Print ISSN: 3060-8589, Published by AccScience Publishing
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here
Accept