AccScience Publishing / AN / Volume 2 / Issue 4 / DOI: 10.36922/an.1913
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The coexistence of narcolepsy and multiple sclerosis: A case report

Jinglong Hu1 Minkai Zhang2 Linjie Yu1 Meijuan Zhang1*
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1 Department of Neurology, Drum Tower Hospital, Medical School and The State Key Laboratory of Pharmaceutical Biotechnology, Institute of Brain Science, Nanjing University, Nanjing, Jiangsu Province, China
2 Department of Neurology, Fourth People’ Hospital of Zhenjiang, Zhenjiang, Jiangsu Province, China
Advanced Neurology 2023, 2(4), 1913
Submitted: 25 September 2023 | Accepted: 28 November 2023 | Published: 14 December 2023
© 2023 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( )

Multiple sclerosis (MS) is a chronic inflammatory demyelinating disorder of the central nervous system, characterized by myelin degeneration. Aside from general symptoms such as visual impairment, muscle weakness, and sensory abnormalities, sleep disorders are sometimes experienced by MS patients. Here, we report a rare case of a 21-year-old young male patient presenting with both MS and narcolepsy. Moreover, we also reviewed the potential pathophysiological mechanisms that linked these two diseases, including the involvement of the immune system and neuronal damage. This case report emphasized the significance of further research into the relationship between MS and narcolepsy and provided a valuable theoretical basis that MS might be a key cause of narcolepsy. In addition, therapeutic strategies for MS, such as ofatumumab, might help alleviate narcolepsy.

Multiple sclerosis
Sleep disorders
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Conflict of interest
The authors declare they have no competing interests.
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Advanced Neurology, Electronic ISSN: 2810-9619 Published by AccScience Publishing