AccScience Publishing / AN / Volume 2 / Issue 3 / DOI: 10.36922/an.1394

Estimated glomerular filtration rate and serum neurofilament light chain: Insight from National Health and Nutrition Examination Survey

Jiangwen Liu1*
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1 Department of Cardiology, 928 Hospital of Joint Logistics Support Force of PLA, Haikou, 571100, Hainan, China
Advanced Neurology 2023, 2(3), 1394
Submitted: 26 July 2023 | Accepted: 14 September 2023 | Published: 27 September 2023
© 2023 by the Authors (s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( )

The neurofilament light chain is a protein biomarker associated with neurodegenerative diseases. Neurofilament light chain levels may increase as kidney function declines due to reduced clearance. However, the relationship between estimated glomerular filtration rate (eGFR) and serum neurofilament light chain (sNfL) has not been extensively studied. Therefore, the objective of this study was to examine the association between eGFR and sNfL levels. Health survey data from 2071 eligible participants in the National Health and Nutrition Examination Survey (NHANES) were used in three multivariate-adjusted weighted linear regression models to analyze the correlation between eGFR and sNfL. Subsequently, segmental linear regression analysis was employed to determine the inflection point of eGFR. Finally, through subgroup analysis, we aimed to assess the impact of all covariates on the association between eGFR and sNfL. According to our results, sNfL levels decreased as eGFR increased. The segmental linear regression model analysis identified an inflection point at 59.9. When eGFR reached 59.9 or exceeded it, each unit increase in eGFR was associated with a 1 pg/mL decrease in sNfL (β = −0.1, P = 0.01). Furthermore, subgroup analysis revealed that hypertension exhibited a significant interaction with the association between eGFR and sNfL (P = 0.01). These findings suggest that eGFR holds promise as a potential marker for neurodegenerative disorders, and hypertension could affect this association to some extent. Moreover, these results could have significant implications for the early detection and prevention of neurodegenerative diseases in patients with kidney disease. However, further research is needed to corroborate these results and elucidate the underlying mechanisms.

Estimated glomerular filtration rate
Serum neurofilament light chain
National Health and Nutrition Examination Survey
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Conflict of interest
The author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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Advanced Neurology, Electronic ISSN: 2810-9619 Published by AccScience Publishing