AccScience Publishing / AN / Volume 1 / Issue 3 / DOI: 10.36922/an.v1i3.278

Tracking of transplanted neural stem cells labeled with superparamagnetic iron oxide in ischemic stroke

Ying Bai1 Zhongqiu Zhou1 Fengchao Zang2 Ling Shen1 Yuan Zhang1 Shuo Leng2 Guangtian Wang3* Bing Han1*
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1 Department of Pharmacology, Jiangsu Provincial Key Laboratory of Critical Care Medicine, School of Medicine, Southeast University, Nanjing, China
2 Department of Radiology, School of Medicine, Southeast University, Nanjing, China
3 School of Basic Medical Sciences, Harbin Medical University, Harbin, China
Advanced Neurology 2022, 1(3), 278
Submitted: 30 November 2022 | Accepted: 9 December 2022 | Published: 27 December 2022
© 2022 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( )

Clinical treatments for ischemic stroke are limited. At present, neural stem cell (NSC) therapy is considered a promising method for treating ischemic stroke. However, the behavior of transplanted NSCs remains ambiguous. Herein, we report the feasibility of superparamagnetic iron oxide labeling for long-time magnetic resonance imaging to track transplanted NSCs in a transient middle cerebral artery occlusion model. According to our studies, in vivo monitoring of transplanted NSCs during ischemic stroke in the current work may provide another insight into the tracking strategy of transplanted NSCs, thereby advancing NSC-based therapy toward clinical application.

Neural stem cell
Ischemic stroke
Superparamagnetic iron oxide
Magnetic resonance imaging
National Natural Science Foundation of China

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Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as potential conflicts of interest.
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Advanced Neurology, Electronic ISSN: 2810-9619 Published by AccScience Publishing