Glioblastoma multiforme (GBM) is an aggressive and lethal brain tumor with limited treatment options and poor prognosis. Standard therapies such as surgery, radiation, and chemotherapy provide modest survival benefits but are often ineffective against tumor recurrence. Tumor treating fields (TTF) therapy has emerged as a promising non-invasive treatment modality that uses alternating electric fields to disrupt cancer cell division and inhibit tumor growth. However, the optimization and practical implementation of TTF systems remain challenging due to limitations in field penetration, electrode design, and treatment efficacy. In this study, we designed and developed a novel TTF prototype system to enhance electric field transmission and optimize therapeutic efficiency. The system incorporates high-dielectric ceramic electrodes made of barium titanate zirconate, allowing for superior field penetration. We evaluated the system through a series of in vitro and in vivo experiments. In vitro, GBM cells exposed to the TTF system exhibited significant reductions in proliferation, with higher field intensities yielding greater inhibition. In vivo, using a rat GBM model, we observed marked tumor suppression, as validated by bioluminescence imaging and magnetic resonance imaging. Survival analysis further demonstrated prolonged lifespan in TTF-treated rats compared to controls. Our findings highlight the potential of this novel TTF system to improve GBM treatment outcomes. This study provides a comprehensive framework for future advancements in TTF therapy, paving the way for clinical translation and further integration with conventional and emerging cancer therapies.