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Sarcomatoid mesothelioma presenting as a mediastinal mass: A case report
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1
Department of Medicine, School of Medicine, Baylor College of Medicine, Houston, Texas,
United States of America
2
Department of Pathology and Immunology, Baylor College of Medicine and Ben Taub Hospital, Houston, Texas,
United States of America
3
Department of Medicine, Baylor College of Medicine, Houston, Texas,
United States of America
Tumor Discovery, 4420 https://doi.org/10.36922/td.4420
Submitted: 2 August 2024 | Accepted: 25 September 2024 | Published: 10 October 2024
(This article belongs to the Special Issue New Developments in Lung Cancer Research, Diagnosis, Treatment, and Prognosis)
© 2024 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
Abstract
Sarcomatoid mesothelioma (SM) is a subtype of mesothelioma, a deadly cancer strongly related to asbestos exposure. Herein, we present the case of a 50-year-old female who presented with back pain and non-specific symptoms for approximately 9 months. The diagnostic investigation revealed a large, centrally necrotic mass in the thorax that appeared to arise from the mediastinum and surrounded vital structures, including the superior vena cava. A biopsy of the thoracic mass revealed SM. The patient developed hematemesis, and emergent endoscopy revealed a gastric ulcer composed of malignant SM cells, a rare finding in pleural mesothelioma. Her disease was too advanced for surgical resection and conventional therapy. She tragically died weeks after diagnosis. The findings of this report highlight the varied presentation of SM to underscore the importance of early diagnosis and treatment of patients in improving overall survival.
Keywords
Mediastinal mass
Dyspnea
Back pain
Sarcomatoid mesothelioma
Lung cancer
Funding
None.
Conflict of interest
The authors declare no conflicts of interest.
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