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REVIEW ARTICLE

Global landscape of organoid biobanks: Bibliometric insights, technological breakthroughs, and clinical translation

Yuxin Su1,2† ,  Yutian Feng2,3† ,  Qingru Song2† ,  Wenrui Ma4 ,  Qi Wang2 ,  Miao Liu4 ,  Wenzhen Yin4 ,  Tanqing Long5 ,  Ni An4 ,  Zhiyuan Hu1,6* ,  Xue Wang7* ,  Zhonghui Zhu8,9* ,  Juan Liu1*
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1 School of Future Medicine, Beijing University of Chinese Medicine, Beijing, China
2 Department of Hepatobiliary and Pancreatic Surgery, Hepato-Pancreato-Biliary Center, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China
3 Department of Biomedical Engineering, School of Biomedical Engineering, Tsinghua University, Beijing, China
4 Clinical Translational Science Center, Beijing Tsinghua Changgung Hospital, Tsinghua University, Beijing, China
5 Department of Pharmacology, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
6 CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, China
7 Department of Developmental Biology, Institute of Developmental Biology and Molecular Medicine, School of Life Sciences, Fudan University, Shanghai, China
8 Department of Occupational and Environmental Health, School of Public Health, Capital Medical University, Beijing, China
9 Beijing Key Laboratory of Environment and Aging, School of Public Health, Capital Medical University, Beijing, China
†These authors contributed equally to this work.
OR, 026210026 https://doi.org/10.36922/OR026210026
Received: 22 May 2026 | Revised: 7 July 2026 | Accepted: 15 July 2026 | Published online: 31 July 2026
© 2026 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
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Abstract

Organoid biobanks represent a pivotal innovation at the intersection of stem cell biology, bioengineering, and precision medicine. By establishing standardized repositories of patient-derived organoids spanning diverse tissues and disease contexts, organoid biobanks enhance experimental reproducibility, foster international scientific collaboration, and accelerate translational research. This study presents a comprehensive bibliometric analysis of 1,318 publications over the past three decades and identifies transformative shifts in the field. Research output has increased substantially since 2014, driven by international consortia involving institutions in China, the United States, and Europe. The analysis highlights predominant applications in cancer modeling (particularly gastrointestinal and central nervous system malignancies), high-throughput drug screening, and regenerative medicine, with emerging frontiers in multi-organ system integration and artificial intelligence-enabled predictive modeling. Technological advances are increasingly being evaluated for clinical relevance through reported concordance between organoid-based predictions and patient treatment responses. While challenges persist in the functional maturation of organoids and in ethical governance, organoid biobanks are increasingly positioned to reshape biomedical research paradigms by bridging experimental models with clinical decision-making. The strategic development of standardized protocols and interdisciplinary frameworks will be essential to realize their full potential in advancing therapeutic discovery and personalized healthcare.

Graphical abstract
Keywords
Organoid biobanking
Patient-derived organoids
Disease modeling
Translational medicine
Multi-omics integration
Funding
This work was supported in part by grants from the National Key Research and Development Program of China (Nos. 2022YFA1103404, 2022YFC2406704) and the National Natural Science Foundation of China (Nos. 32371477, 82572451).
Conflict of interest
The authors declare no conflict of interest.
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Organoid Research, Electronic ISSN: 3082-8503 Published by AccScience Publishing
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