AccScience Publishing / NSCE / Volume 2 / Issue 1 / DOI: 10.36922/NSCE025520019
REVIEW ARTICLE

The dynamical models of sleep: A brief review 

Adriano Scibilia1* Luigi Fortuna2
Show Less
1 1 Institute of Intelligent Industrial Systems and Technologies for Advanced Manufacturing, National Research Council, Milan, Lombardy, Italy
2 2 Department of Engineering, University of Palermo, Palermo, Palermo, Italy
NSCE 2026, 2(1), 025520019 https://doi.org/10.36922/NSCE025520019
Received: 23 December 2025 | Revised: 2 March 2026 | Accepted: 10 March 2026 | Published online: 24 April 2026
© 2026 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution -Noncommercial 4.0 International License (CC-by the license) ( https://creativecommons.org/licenses/by-nc/4.0/ )
Abstract

The field of sleep dynamics is a fascinating and complex area of research. The topic of sleep has attracted widespread interest over the last century. The aim of this concise review is to provide some essential items for researchers interested in both nonlinear science and sleep engineering. In particular, the paper focuses on the dynamical modeling of sleep, highlighting the fundamental mechanisms underlying sleep–wake regulation. A brief literature review is presented, and some fundamental mathematical models of sleep are reported with numerical simulations. This review introduces the reader to the fascinating topic of sleep dynamics, underlining its universality and complexity, and stimulates further research in the field.

Keywords
Sleep dynamics
Nonlinear systems
Circadian rhythms
Homeostatic regulation
Chaos theory
Complex systems
Funding
None.
Conflict of interest
Luigi Fortuna is the Honorary Editor-in-Chief of this journal, but was not in any way involved in the editorial and peer-review process conducted for this paper, directly or indirectly. Separately, other authors declared that they have no known competing financial interests or personal relationships that could have influenced the work reported in this paper.
References
  1. Walker M. Why We Sleep: Unlocking the Power of Sleep and Dreams. Scribner. 2017.

 

  1. Rattenborg NC, Ungurean G. The evolution and diversification of sleep. Trends in Ecology & Evolution. 2023;38(2):156-170. https://www.doi.org/10.1016/j.tree.2022.10.004

 

  1. Roth TC, Lesku JA, Amlaner CJ, Lima SL. A phylogenetic analysis of the correlates of sleep in birds. J Sleep Res. 2006;15(4):395-402. https://www.doi.org/10.1111/j.1365-2869.2006.00559.x

 

  1. Sauer S, Herrmann E, Kaiser W. Sleep deprivation in honey bees. J Sleep Res. 2004;13(2):145-152. https://www.doi.org/10.1111/j.1365-2869.2004.00393.x

 

  1. Lima SL, Rattenborg NC, Lesku JA, Amlaner CJ. Sleeping under the risk of predation. Anim Behav. 2005;70(4):723-736. https://www.doi.org/10.1016/j.anbehav.2005.01.008

 

  1. Vyazovskiy VV, Tobler I, Gilestro GF. The temporal structure of behaviour and sleep homeostasis. PLoS One. 2012;7(12):e50677. https://www.doi.org/10.1371/journal.pone.0050677

 

  1. Rich MM, Wenner P. Sensing and expressing homeostatic synaptic plasticity. Trends in Neurosci. 2007;30(3):119-125. https://www.doi.org/10.1016/j.tins.2007.01.004

 

  1. Siegel JM. Sleep function: an evolutionary perspective. Lancet Neurol. 2022;21(10):937-946. https://www.doi.org/10.1016/S1474-4422(22)00210-1

 

  1. Dudley CA, Erbel-Sieler C, Estill SJ, et al. Altered patterns of sleep and behavioral adaptability in NPAS2-deficient mice. Sci. 2003;301(5631):379-383. https://www.doi.org/10.1126/science.1082795

 

  1. Olbrich E, Claussen JC, Achermann P. The multiple time scales of sleep dynamics as a challenge for modelling the sleeping brain. Philos Trans A Math Phys Eng Sci. 2011;369(1952):3884-3901. https://www.doi.org/10.1098/rsta.2011.0082

 

  1. Borbely AA. A two process model of sleep regulation. Hum Neurobiol. 1982;1(3):195-204.

 

  1. Phillips AJK, Robinson PA. A quantitative model of sleep-wake dynamics based on the physiology of the brainstem ascending arousal system. J Biol Rhythms. 2007;22(2):167-179. https://www.doi.org/10.1177/0748730406297512

 

  1. Comte JC, Ravassard P, Salin PA. Sleep dynamics: a self-organized critical system. Phys Rev E Stat Nonlin Soft Matter Phys. 2006;73(5):056127. https://www.doi.org/10.1103/PhysRevE.73.056127

 

  1. Sorensen GL, Knudsen S, Jennum P. Sleep transitions in hypocretin-deficient narcolepsy. Sleep. 2013;36(8):1173-1177. https://www.doi.org/ 10.5665/sleep.2880

 

  1. Prerau MJ, Brown RE, Bianchi MT, Ellenbogen JM, Purdon PL. Tracking the sleep onset process: an empirical model of behavioral and physiological dynamics. PLoS Comput Biol. 2014;10(10):e1003866. https://www.doi.org/10.1371/journal.pcbi.1003866

 

  1. Yetton BD, McDevitt EA, Cellini N, Shelton C, Mednick SC. Quantifying sleep architecture dynamics and individual differences using Bayesian networks. PLoS One. 2018;13(4):e0194604. https://www.doi.org/10.1371/journal.pone.0194604

 

  1. Basner M, Rao H, Goel N, Dinges DF. Sleep deprivation and neurobehavioral dynamics. Curr Opin Neurobiol. 2013;23(5):854-863. https://www.doi.org/10.1016/j.conb.2013.02.008.

 

  1. Chen PC, Niknazar H, Alaynick WA, Whitehurst LN, Mednick SC. Competitive dynamics underlie cognitive improvements during sleep. Proc Natl Acad Sci. 2021;118(51):e2109339118. https://www.doi.org/10.1073/pnas.2109339118

 

  1. Gottesman RF, Lutsey PL, Benveniste H, et al. Impact of Sleep Disorders and Disturbed Sleep on Brain Health: A Scientific Statement From the American Heart Association. Stroke. 2024;55(3). https://www.doi.org/10.1161/str.0000000000000453

 

  1. Rempe MJ, Best J, Terman D. A mathematical model of the sleep/wake cycle. J Math Biol. 2010;60(5):615-644. https://www.doi.org/10.1007/s00285-009-0276-5

 

  1. Kharchenko V, Zhdanova IV. The wave model of sleep dynamics and an invariant relationship between non-REM and REM sleep. Clocks & Sleep. 2023;5(4):686-716. https://www.doi.org/10.3390/clockssleep5040046

 

  1. Viswanath VK, HartogenesisW, Dilchert S, et al. Five million nights: temporal dynamics in human sleep phenotypes. Npj Digit Med. 2024;7(1). https://www.doi.org/10.1038/s41746-024-01125-5

 

  1. Robinson PA, Phillips AJK, Fulcher BD, Puckeridge M, Roberts JA. Quantitative modelling of sleep dynamics. Philos Trans A Math Phys Eng Sci. 2011;369(1952):3840-3854. https://www.doi.org/10.1098/rsta.2011.0120

 

  1. Babloyantz A, Salazar JM, Nicolis C. Evidence of chaotic dynamics of brain activity during the sleep cycle. Phys Lett A. 1985;111(3):152-156. https://www.doi.org/10.1016/0375-9601(85)90444-X

 

  1. Roschke J, Ba,sar E. The EEG is Not a Simple Noise: Strange Attractors in Intracranial Structures. In: Springer Series in Brain Dynamics. Springer Berlin Heidelberg; 1988:203-216. https://www.doi.org/10.1007/978-3-642-71531-0_13

 

  1. Fell J, Roschke J, Beckmann P. Deterministic chaos and the first positive Lyapunov exponent: a nonlinear analysis of the human electroencephalogram during sleep. Biol Cybern. 1993;69(2):139-146. https://www.doi.org/10.1007/BF00226197

 

  1. Fell J, Roschke J, Mann K. Discrimination of sleep stages: a comparison between spectral and nonlinear EEG measures. Electroencephalogr Clin Neurophysiol. 1996;98(5):401-410. https://www.doi.org/10.1016/0013-4694(96)95636-9

 

  1. Kruglikov SY, Schiff SJ. Interplay of electroencephalogram phase and auditory-evoked neural activity. J Neurosci. 2003;23(31):10122-10127. https://www.doi.org/10.1523/JNEUROSCI.23-31-10122.2003

 

  1. Behn CGD, Booth V. A fast–slow analysis of the dynamics of REM sleep. SIAM J Appl Dyn Syst. 2012;11(1):212-242. https://www.doi.org/10.1137/110832823

 

  1. Booth V, Xique I, Diniz Behn, CG. One-dimensional map for the circadian modulation of sleep in a sleep-wake regulatory network model for human sleep. SIAM J Appl Dyn Syst. 2017;16(2):1089-1112. https://www.doi.org/10.1137/16M1071328

 

  1. Postnova S, Voigt K, Braun HA. A Mathematical Model of Homeostatic Regulation of Sleep-Wake Cycles by Hypocretin/Orexin. J Biol Rhythms. 2009;24(6):523-535. https://www.doi.org/10.1177/0748730409346655

 

  1. Hutt A, Longtin A. Effects of the anesthetic agent propofol on neural populations. Cogn Neurodyn. 2009;4(1):37-59. https://www.doi.org/10.1007/s11571-009-9092-2

 

  1. Paul K, Cauller LJ, Llano DA. Presence of a chaotic region at the sleep–wake transition in a simplified thalamocortical circuit model. Front Comput Neurosci. 2016;10:91. https://www.doi.org/10.3389/fncom.2016.00091

 

  1. Rasmussen R, Jensen MH, Heltberg ML. Chaotic Dynamics Mediate Brain State Transitions, Driven by Changes in Extracellular Ion Concentrations. Cell Systems. 2017;5(6):591-603.e4. https://www.doi.org/10.1016/j.cels.2017.11.011

 

  1. Achermann P, Borbely AA. Temporal evolution of coherence and power in the human sleep electroencephalogram. J Sleep Res. 1998;7(S1):36-41. https://www.doi.org/10.1046/j.1365-2869.7.s1.6.x

 

  1. Massimini M, Huber R, Ferrarelli F, Hill S, Tononi G. The Sleep Slow Oscillation as a Traveling Wave. J Neurosci. 2004;24(31):6862-6870. https://www.doi.org/10.1523/jneurosci.1318-04.2004

 

  1. Foroutannia A, Nazarimehr F, Ghasemi M, Jafari S. Chaos in memory function of sleep: A nonlinear dynamical analysis in thalamocortical study. J Theor Biol. 2021;528:110837. https://www.doi.org/10.1016/j.jtbi.2021.110837

 

  1. Granada AE, Herzel H. How to Achieve Fast Entrainment? The Timescale to Synchronization. Khanin R, ed. PLoS ONE. 2009;4(9):e7057. https://www.doi.org/10.1371/journal.pone.0007057

 

  1. Yang DP, McKenzie-Sell L, Karanjai A, Robinson PA. Wake-sleep transition as a noisy bifurcation. Phys Rev E. 2016;94(2). https://www.doi.org/10.1103/physreve.94.022412

 

  1. Duarte CD, Pacheco M, Iaconis FR, et al. Statistical complexity analysis of sleep stages. Entropy. 2025;27(1):76. https://www.doi.org/10.3390/e27010076

 

  1. Skeldon AC, Dijk DJ. The complexity and commonness of the two-process model of sleep regulation from a mathematical perspective. npj Biol Timing Sleep. 2025;2(1). https://www.doi.org/10.1038/s44323-025-00039-z

 

  1. Ji Y, Xu F, Shuai J, Yang D, Yao C. Dynamical mechanism for the interplay of circadian, homeostatic, and ultradian rhythm in normal human sleep. Phys Rev E. 2025;111(4). https://www.doi.org/10.1103/physreve.111.044215

 

  1. Yao C, Yang D. Mechanistic modeling of sleep–wake transitions via circadian-modulated threshold dynamics. bioRxiv. Preprint online July 15, 2025. https://www.doi.org/ 10.1101/2025.07.10.664059

 

  1. Sun H., Ishbulatov Y., Karavaev A., Zakharov D., Zaikin A. A thermodynamic model of the REM–NREM sleep cycle. Chaos, Solitons & Fractals. 2025;190:115732. https://www.doi.org/ 10.1016/j.chaos.2024.115732

 

  1. Athanasouli C, Stowe SR, LeBourgeois MK, Booth V, Diniz Behn CG. Data-driven mathematical modeling of sleep consolidation in early childhood. J Theor Biol. 2024;593: 111892. https://www.doi.org/10.1016/j.jtbi.2024.111892

 

  1. Ginsberg AG, Cruz MEC, Weber F, Booth V, Diniz Behn CG. A predictive propensity measure to enter REM sleep. Front Neurosci. 2024;18. https://www.doi.org/10.3389/fnins.2024.1431407

 

  1. Phillips AJK, Robinson PA. A Quantitative Model of Sleep-Wake Dynamics Based on the Physiology of the Brainstem Ascending Arousal System. J Biol Rhythms. 2007;22(2):167-179. https://www.doi.org/10.1177/0748730406297512

 

  1. McCauley ME, Van Dongen HPA, Belenky G, et al. The dynamics of neurobehavioral impairment and recovery after sleep loss. Front Environ Health. 2024;3:1362755. https://www.doi.org/10.3389/fenvh.2024.1362755

 

  1. Kinoshita T, Tatsuki F, Yoshida Y, et al. A unified framework to model synaptic dynamics during the sleep–wake cycle. PLoS Biol. 2025;23(6):e3003198. https://www.doi.org/10.1371/journal.pbio.3003198

 

  1. Putilov AA. Can the Brain’s Thermostatic Mechanism Generate Sleep-Wake and NREM-REM Sleep Cycles? A Nested Doll Model of Sleep-Regulating Processes. Clocks & Sleep. 2024;6(1):97-113. https://www.doi.org/10.3390/clockssleep6010008
Share
Back to top
Nonlinear Science and Control Engineering, Published by AccScience Publishing