Site-specific pharmaco-laser therapy: A novel treatment modality for refractory port wine stains
Despite extensive efforts to optimize laser therapy, i.e., the current gold standard treatment, a majority of port wine stain patients responds suboptimally to laser therapy. This paper describes the niceties of a novel port wine stain treatment modality termed site-specific pharmaco-laser therapy (SSPLT). In contrast to the classic approach of enhancing the extent of intravascular photocoagulation (the photothermal response), SSPLT focuses on optimization of post-irradiation thrombus formation (i.e., the hemodynamic response) by combining conventional laser therapy with the administration of thermosensitive drug delivery systems that encapsulate prothrombotic and antifibrinolytic drugs. The aim is to instill complete lumenal occlusion of target vessels, which has been linked to optimal port wine stain blanching.
Relevance for patients: Current treatment options for port wine stain patients are limited in efficacy. Novel therapeutic modalities are needed to more effectively treat patients with recalcitrant port wine stains. SSPLT is an experimental-stage treatment modality that could serve as an adjuvant to pulsed dye laser therapy for a select group of patients whose port wine stain is ill-responsive to standard treatment. The expected clinical result of SSPLT is improved lesional blanching.
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