AccScience Publishing / JCTR / Volume 2 / Issue 3 / DOI: 10.18053/jctres.02.201603.004
EDITORIAL

The rush to novelty and high expectations in surgery: the case of ALPPS

Pim B Olthof1* Erik Schadde2,3,4
Show Less
1 Department of Experimental Surgery, Academic Medical Center, Amsterdam, the Netherlands
2 Department of Surgery, Division of Transplantation, Rush University Medical Center, Chicago, IL, United States
3 Department of Surgery, Cantonal Hospital Winterthur, Kanton Zurich, Switzerland
4 Institute of Physiology, Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
Published: 12 September 2016
© 2016 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution -Noncommercial 4.0 International License (CC-by the license) ( https://creativecommons.org/licenses/by-nc/4.0/ )
Conflict of interest
The authors declare they have no competing interests.
References

[1] Schnitzbauer AA, Lang SA, Goessmann H, Nadalin S, Baum gart J, Farkas SA, Fichtner-Feigl S, Lorf T, Goralcyk A, Hor belt R, Kroemer A, Loss M, Rummele P, Scherer MN, Padberg W, Konigsrainer A, Lang H, Obed A, Schlitt HJ. Right portal vein ligation combined with in situ splitting induces rapid left lateral liver lobe hypertrophy enabling 2-staged extended right hepatic resection in small-for-size settings. Ann Surg 2012; 255: 405-414.

[2] de Santibanes E, Clavien PA. Playing play-doh to prevent postoperative liver failure: The "alpps" approach. Ann Surg 2012; 255: 415-417.

[3] Aloia TA, Vauthey JN. Associating liver partition and portal vein ligation for staged hepatectomy (alpps): What is gained and what is lost? Ann Surg 2012; 256: e9; author reply e16-19.

[4] Dokmak S, Belghiti J. Which limits to the "alpps" approach? Ann Surg 2012; 256: e6; author reply e16-17.

[5] Vigano L, Cimino MM, Torzilli G, Adam R. Improving the safety of alpps procedure: The optimal compromise between dropout and mortality risk. Comment on schadde e et al pre diction of mortality after alpps stage-1: An analysis of 320 pa tients from the international alpps registry. Ann surg. 2015; 262: 780-786. Ann Surg 2016; Epubahead of print.

[6] Schadde E, Schnitzbauer AA, Tschuor C, Raptis DA, Bec hstein WO, Clavien PA. Systematic review and meta-analysis of feasibility, safety, and efficacy of a novel procedure: Asso ciating liver partition and portal vein ligation for staged hepa tectomy. Ann Surg Oncol 2015; 22: 3109-3120.

[7] Schadde E, Ardiles V, Robles-Campos R, Malago M, Machado M, Hernandez-Alejandro R, Soubrane O, Schnitzbauer AA, Raptis D, Tschuor C, Petrowsky H, De Santibanes E, Clavien PA, Group AR. Early survival and safety of alpps: First report of the international alpps registry. Ann Surg 2014; 260: 829- 836; discussion 836-838.

[8] Schadde E, Raptis DA, Schnitzbauer AA, Ardiles V, Tschuor C, Lesurtel M, Abdalla EK, Hernandez-Alejandro R, Jovine E, Machado M, Malago M, Robles-Campos R, Petrowsky H, Santibanes ED, Clavien PA. Prediction of mortality after alpps stage-1: An analysis of 320 patients from the international alpps registry. Ann Surg 2015; 262: 780-785; discussion 785-786.

[9] Lee MKt, Gao F, Strasberg SM. Completion of a liver surgery complexity score and classification based on an international survey of experts. J Am Coll Surg 2016; 223: 332-342.

[10] Bioulac-Sage P, Laumonier H, Couchy G, Le Bail B, Sa Cunha A, Rullier A, Laurent C, Blanc JF, Cubel G, Trillaud H, Zucman-Rossi J, Balabaud C, Saric J. Hepatocellular adenoma management and phenotypic classification: The bordeaux ex perience. Hepatology 2009; 50: 481-489.

[11] Mansour JC, Aloia TA, Crane CH, Heimbach JK, Nagino M, Vauthey JN. Hilar cholangiocarcinoma: Expert consensus statement. HPB (Oxford) 2015; 17: 691-699.

[12] Capussotti L, Muratore A, Baracchi F, Lelong B, Ferrero A, Regge D, Delpero JR. Portal vein ligation as an efficient method of increasing the future liver remnant volume in the surgical treatment of colorectal metastases. Arch Surg 2008; 143: 978-982; discussion 982.

[13] Abulkhir A, Limongelli P, Healey AJ, Damrah O, Tait P, Jack son J, Habib N, Jiao LR. Preoperative portal vein embolization for major liver resection: A meta-analysis. Ann Surg 2008; 247: 49-57.

[14] Shindoh J, Vauthey JN, Zimmitti G, Curley SA, Huang SY, Mahvash A, Gupta S, Wallace MJ, Aloia TA. Analysis of the efficacy of portal vein embolization for patients with extensive liver malignancy and very low future liver remnant volume, including a comparison with the associating liver partition with portal vein ligation for staged hepatectomy approach. J Am Coll Surg 2013; 217: 126-133; discussion 133-134.

[15] Oldhafer KJ, Stavrou GA, van Gulik TM, Core G. Alpps- where do we stand, where do we go?: Eight recommendations from the first international expert meeting. Ann Surg 2016; 263: 839-841.

[16] Robles R, Parrilla P, Lopez-Conesa A, Brusadin R, de la Pena J, Fuster M, Garcia-Lopez JA, Hernandez E. Tourniquet modi-fication of the associating liver partition and portal ligation for staged hepatectomy procedure. Br J Surg 2014; 101: 1129- 1134; discussion 1134.

[17] Gall TM, Sodergren MH, Frampton AE, Fan R, Spalding DR, Habib NA, Pai M, Jackson JE, Tait P, Jiao LR. Radio-fre quency-assisted liver partition with portal vein ligation (ralpp) for liver regeneration. Ann Surg 2015; 261: e45-46.

[18] Petrowsky H, Gyori G, de Oliveira M, Lesurtel M, Clavien PA. Is partial-alpps safer than alpps? A single-center experience. Ann Surg 2015; 261: e90-92.

[19] Ettorre GM, Guglielmo N, Meniconi RL, Sandri GB, Co lasanti M, Vennarecci G. Segment 4: A key point of alpps pro cedure. Ann Surg 2016; Epubahead of print.

[20] McCulloch P, Altman DG, Campbell WB, Flum DR, Glasziou P, Marshall JC, Nicholl J, Balliol C, Aronson JK, Barkun JS, Blazeby JM, Boutron IC, Campbell WB, Clavien PA, Cook JA, Ergina PL, Feldman LS, Flum DR, Maddern GJ, Nicholl J, Reeves BC, Seiler CM, Strasberg SM, Meakins JL, Ashby D, Black N, Bunker J, Burton M, Campbell M, Chalkidou K, Chalmers I, de Leval M, Deeks J, Ergina PL, Grant A, Gray M, Greenhalgh R, Jenicek M, Kehoe S, Lilford R, Littlejohns P, Loke Y, Madhock R, McPherson K, Meakins J, Rothwell P, Summerskill B, Taggart D, Tekkis P, Thompson M, Treasure T, Trohler U, Vandenbroucke J. No surgical innovation without evaluation: The ideal recommendations. Lancet 2009; 374: 1105-1112.

[21] Ratti F, Schadde E, Masetti M, Massani M, Zanello M, Sere nari M, Cipriani F, Bonariol L, Bassi N, Aldrighetti L, Jovine E. Strategies to increase the resectability of patients with col orectal liver metastases: A multi-center case-match analysis of alpps and conventional two-stage hepatectomy. Ann Surg On col 2015; 22: 1933-1942.

[22] Imai K, Benitez CC, Allard MA, Vibert E, Cunha AS, Cherqui D, Castaing D, Bismuth H, Baba H, Adam R. Failure to achieve a 2-stage hepatectomy for colorectal liver metastases: How to prevent it? Ann Surg 2015; 262: 772-778; discussion 778-779.

[23] Schadde E, Ardiles V, Slankamenac K, Tschuor C, Sergeant G, Amacker N, Baumgart J, Croome K, Hernandez-Alejandro R, Lang H, de Santibanes E, Clavien PA. Alpps offers a better chance of complete resection in patients with primarily unre sectable liver tumors compared with conventional-staged hepatectomies: Results of a multicenter analysis. World J Surg 2014; 38: 1510-1519.

[24] Oldhafer KJ, Donati M, Jenner RM, Stang A, Stavrou GA. Alpps for patients with colorectal liver metastases: Effective liver hypertrophy, but early tumor recurrence. World J Surg 2014; 38: 1504-1509.

[25] Bjornsson B, Sparrelid E, Rosok B, Pomianowska E, Has selgren K, Gasslander T, Bjornbeth BA, Isaksson B, Sand strom P. Associating liver partition and portal vein ligation for staged hepatectomy in patients with colorectal liver metastases - intermediate oncological results. Eur J Surg Oncol 2016; 42: 531-537.

[26] Alvarez FA, Ardiles V, de Santibanes M, Pekolj J, de Santi banes E. Associating liver partition and portal vein ligation for staged hepatectomy offers high oncological feasibility with adequate patient safety: A prospective study at a single center. Ann Surg 2015; 261: 723-732.

[27] Schadde E, Malago M, Hernandez-Alejandro R, Li J, Abdalla E, Ardiles V, Lurje G, Vyas S, Machado MA, de Santibanes E. Monosegment alpps hepatectomy: Extending resectability by rapid hypertrophy. Surgery 2015; 157: 676-689.

[28] Vyas SJ, Davies N, Grant L, Imber CJ, Sharma D, Davidson BR, Malago M, Fusai G. Failure of portal venous embolization. Alpps as salvage enabling successful resection of bilobar liver metastases. J Gastrointest Cancer 2014; 45 Suppl 1: 233-236.

[29] Tschuor C, Croome KP, Sergeant G, Cano V, Schadde E, Ar diles V, Slankamenac K, Claria RS, de Santibanes E, Hernan dez-Alejandro R, Clavien PA. Salvage parenchymal liver transection for patients with insufficient volume increase after portal vein occlusion -- an extension of the alpps approach. Eur J Surg Oncol 2013; 39: 1230-1235.

[30] Croome KP, Hernandez-Alejandro R, Parker M, Heimbach J, Rosen C, Nagorney DM. Is the liver kinetic growth rate in alpps unprecedented when compared with pve and living do nor liver transplant? A multicentre analysis. HPB (Oxford) 2015; 17: 477-484.

[31] Truant S, Baillet C, Deshorgue AC, Leteurtre E, Hebbar M, Ernst O, Huglo D, Pruvot FR. Drop of total liver function in the interstages of the new associating liver partition and portal vein ligation for staged hepatectomy technique: Analysis of the "auxiliary liver" by hida scintigraphy. Ann Surg 2016; 263: e33-34.

[32] Cieslak KP, Olthof PB, van Lienden KP, Besselink MG, Busch OR, van Gulik TM, Bennink RJ. Assessment of liver function using (99m)tc-mebrofenin hepatobiliary scintigraphy in alpps (associating liver partition and portal vein ligation for staged hepatectomy). Case Rep Gastroenterol 2015; 9: 353-360.

[33] Matsuo K, Murakami T, Kawaguchi D, Hiroshima Y, Koda K, Yamazaki K, Ishida Y, Tanaka K. Histologic features after surgery associating liver partition and portal vein ligation for staged hepatectomy versus those after hepatectomy with portal vein embolization. Surgery 2016; 159: 1289-1298.

[34] Garcia-Perez R, Revilla-Nuin B, Martinez CM, Bernabe- Gar cia A, Baroja Mazo A, Parrilla Paricio P. Associated liver par tition and portal vein ligation (alpps) vs selective portal vein ligation (pvl) for staged hepatectomy in a rat model. Similar regenerative response? PLoS One 2015; 10: e0144096.

[35] Shi H, Yang G, Zheng T, Wang J, Li L, Liang Y, Xie C, Yin D, Sun B, Sun J, Wang H, Pan S, Jiang H, Lau W, Liu L. A pre liminary study of alpps procedure in a rat model. Sci Rep 2015; 5: 17567.

[36] Wei W, Zhang T, Zafarnia S, Schenk A, Xie C, Kan C, Dirsch O, Settmacher U, Dahmen U. Establishment of a rat model: Associating liver partition with portal vein ligation for staged hepatectomy. Surgery 2016; 159: 1299-1307.

[37] Schlegel A, Lesurtel M, Melloul E, Limani P, Tschuor C, Graf R, Humar B, Clavien PA. Alpps: From human to mice high lighting accelerated and novel mechanisms of liver regenera tion. Ann Surg 2014; 260: 839-846; discussion 846-837.

[38] Croome KP, Mao SA, Glorioso JM, Krishna M, Nyberg SL, Nagorney DM. Characterization of a porcine model for asso ciating liver partition and portal vein ligation for a staged hepatectomy. HPB (Oxford) 2015; 17: 1130-1136.

[39] Buac S, Schadde E, Schnitzbauer AA, Vogt K, Hernandez- Alejandro R. The many faces of alpps: Surgical indications and techniques among surgeons collaborating in the interna tional registry. HPB (Oxford) 2016; 18: 442-448.

[40] Knoefel WT, Gabor I, Rehders A, Alexander A, Krausch M, Schulte am Esch J, Furst G, Topp SA. In situ liver transection with portal vein ligation for rapid growth of the future liver remnant in two-stage liver resection. Br J Surg 2013; 100: 388-394.

[41] Li J, Kantas A, Ittrich H, Koops A, Achilles EG, Fischer L, Nashan B. Avoid "all-touch" by hybrid alpps to achieve onco logical efficacy. Ann Surg 2016; 263: e6-7.

[42] de Santibanes E, Alvarez FA, Ardiles V, Pekolj J, de Santi banes M. Inverting the alpps paradigm by minimizing first stage impact: The mini-alpps technique. Langenbecks Arch Surg 2016; 401: 557-563.

Share
Back to top
Journal of Clinical and Translational Research, Electronic ISSN: 2424-810X Print ISSN: 2382-6533, Published by AccScience Publishing